Please use this identifier to cite or link to this item:
Type: Artigo
Title: Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts
Author: Baker, W. B.
Parthasarathy, A. B.
Ko, T. S.
Busch, D. R.
Abramson, K.
Tzeng, S.-Y.
Mesquita, R. C.
Durduran, T.
Greenberg, J. H.
Kung, D. K.
Yodh, A. G.
Abstract: We introduce and validate a pressure measurement paradigm that reduces extracerebral contamination from superficial tissues in optical monitoring of cerebral blood flow with diffuse correlation spectroscopy (DCS). The scheme determines subject-specific contributions of extracerebral and cerebral tissues to the DCS signal by utilizing probe pressure modulation to induce variations in extracerebral blood flow. For analysis, the head is modeled as a two-layer medium and is probed with long and short source-detector separations. Then a combination of pressure modulation and a modified Beer-Lambert law for flow enables experimenters to linearly relate differential DCS signals to cerebral and extracerebral blood flow variation without a priori anatomical information. We demonstrate the algorithm's ability to isolate cerebral blood flow during a finger-tapping task and during graded scalp ischemia in healthy adults. Finally, we adapt the pressure modulation algorithm to ameliorate extracerebral contamination in monitoring of cerebral blood oxygenation and blood volume by near-infrared spectroscopy.
Subject: Espectroscopia de correlação de difusão
Espectroscopia de infravermelho próximo
Cérebro - Imagem
Circulação cerebral
Acidente vascular cerebral
Diffuse correlation spectroscopy
Near infrared spectroscopy
Brain - Imaging
Cerebral circulation
Country: Estados Unidos
Editor: SPIE - International Society for Optical Engineering
Rights: aberto
Identifier DOI: 10.1117/1.NPh.2.3.035004
Date Issue: 2015
Appears in Collections:IFGW - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000370540100013.pdf1.96 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.