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Type: Artigo
Title: Evaluating methods for the isolation of marine-derived fungal strains and production of bioactive secondary metabolites
Author: Kossuga, Miriam H.
Romminger, Stelamar
Xavier, Camila
Milanetto, Marília C.
Valle, Milene Z. do
Pimenta, Eli F.
Morais, Raquel P.
Carvalho, Erica de
Mizuno, Carolina M.
Coradello, Luís Fernando C.
Barroso, Vinícius de M.
Vacondio, Bruna
Javaroti, Darci C. D.
Seleghim, Mirna H. R.
Cavalcanti, Bruno C.
Pessoa, Claudia
Moraes, Manoel O.
Lima, Bruna A.
Gonçalves, Reginaldo
Bonugli-Santos, Rafaella C.
Sette, Lara D.
Berlinck, Roberto G. S.
Abstract: In the present investigation we evaluate methods for the isolation and growth of marine-derived fungal strains in artificial media for the production of secondary metabolites. Inoculation of marine macroorganisms fragments in Petri dishes proved to be the most convenient procedure for the isolation of the largest number of strains. Among the growth media used, 3% malt extract showed the best result for strains isolation and growth, and yielded the largest number of strains from marine macroorganisms. The percentage of strains isolated using each of the growth media which yielded cytotoxic and/or antibiotic extracts was in the range of 23-35%, regardless of the growth media used. Further investigation of extracts obtained from different marine-derived fungal strains yielded several bioactive secondary metabolites, among which (E)-4-methoxy-5-(3-methoxybut-1-enyl)-6-methyl-2H-pyran-2-one is a new metabolite isolated from the Penicillium paxilli strain Ma(G)K.
Subject: Agentes antiinfecciosos
Country: Brasil
Editor: Springer
Rights: Aberto
Identifier DOI: 10.1590/S0102-695X2011005000222
Date Issue: 2012
Appears in Collections:FOP - Artigos e Outros Documentos

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