Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348248
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBrandão, Maria Angela Bellomo-
dc.contributor.authorunicampCosta, Sandra Cecília Botelho-
dc.contributor.authorunicampEscanhoela, Cecília Amélia Fazzio-
dc.contributor.authorunicampVassallo, José-
dc.contributor.authorunicampDe Tommaso, Adriana Maria Alves-
dc.contributor.authorunicampHessel, Gabriel-
dc.typeArtigopt_BR
dc.titleCytomegalovirus frequency in neonatal intrahepatic cholestasis determined by serology, histology, immunohistochemistry and PCRpt_BR
dc.contributor.authorBellomo-Brandao, Maria Angela-
dc.contributor.authorAndrade, Paula D-
dc.contributor.authorCosta, Sandra C B-
dc.contributor.authorEscanhoela, Cecilia A F-
dc.contributor.authorVassallo, Jose-
dc.contributor.authorPorta, Gilda-
dc.contributor.authorDe Tommaso, Adriana M A-
dc.contributor.authorHessel, Gabriel-
dc.subjectCitomegalovíruspt_BR
dc.subjectImuno-histoquímicapt_BR
dc.subject.otherlanguageCytomegaloviruspt_BR
dc.subject.otherlanguageImmunohistochemistrypt_BR
dc.description.abstractTo determine cytomegalovirus (CMV) frequency in neonatal intrahepatic cholestasis by serology, histological revision (searching for cytomegalic cells), immunohistochemistry, and polymerase chain reaction (PCR), and to verify the relationships among these methods. The study comprised 101 non-consecutive infants submitted for hepatic biopsy between March 1982 and December 2005. Serological results were obtained from the patient's files and the other methods were performed on paraffin-embedded liver samples from hepatic biopsies. The following statistical measures were calculated: frequency, sensibility, specific positive predictive value, negative predictive value, and accuracy. The frequencies of positive results were as follows: serology, 7/64 (11%); histological revision, 0/84; immunohistochemistry, 1/44 (2%), and PCR, 6/77 (8%). Only one patient had positive immunohistochemical findings and a positive PCR. The following statistical measures were calculated between PCR and serology: sensitivity, 33.3%; specificity, 88.89%; positive predictive value, 28.57%; negative predictive value, 90.91%; and accuracy, 82.35%. The frequency of positive CMV varied among the tests. Serology presented the highest positive frequency. When compared to PCR, the sensitivity and positive predictive value of serology were lowpt_BR
dc.relation.ispartofWorld journal of gastroenterologypt_BR
dc.relation.ispartofabbreviationWorld j. gastroenterol.pt_BR
dc.publisher.cityPleasanton, CApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherBaishidengpt_BR
dc.date.issued2012-
dc.date.monthofcirculationJulypt_BR
dc.language.isoengpt_BR
dc.description.volume15pt_BR
dc.description.issuenumber27pt_BR
dc.description.firstpage3411pt_BR
dc.description.lastpage3416pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1007-9327pt_BR
dc.identifier.eissn2219-2840pt_BR
dc.identifier.doi10.3748/wjg.15.3411pt_BR
dc.identifier.urlhttps://www.wjgnet.com/1007-9327/full/v15/i27/3411.htmpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.date.available2020-08-28T17:42:12Z-
dc.date.accessioned2020-08-28T17:42:12Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-08-28T17:42:12Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:14:34Z : No. of bitstreams: 1 000268265000011.pdf: 884150 bytes, checksum: e29dc021b8a754644262c9c8b3ebbcc3 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-08-28T17:42:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348248-
dc.contributor.departmentDepartamento de Pediatriapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Pediatriapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordHepatitispt_BR
dc.subject.keywordNeonatalpt_BR
dc.identifier.source000268265000011pt_BR
dc.creator.orcid0000-0002-1145-2606pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-2192-4865pt_BR
dc.creator.orcid0000-0001-7077-9804pt_BR
dc.creator.orcid0000-0002-9884-9381pt_BR
dc.type.formArtigopt_BR
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