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Type: Artigo
Title: Incidence and risk factors of aplastic anemia in Latin American countries: the LATIN case-control study
Author: Maluf, Eliane
Hamerschlak, Nelson
Cavalcanti, Alexandre Biasi
Avezum Junior, Alvaro
Eluf-Neto, Jose
Falcao, Roberto Passetto
Lorand-Metze, Irene G.
Goldenberg, Daniel
Santana, Cezar Leite
Werneck Rodrigues, Daniela de Oliveira
da Motta Passos, Leny Nascimento
Mange Rosenfeld, Luis Gastao
Pitta, Marimilia
Loggetto, Sandra
Feitosa Ribeiro, Andreza A.
Velloso, Elvira Deolinda
Kondo, Andrea Tiemi
de Miranda Coelho, Erika Oliveira
ostes Pintao, Maria Carolina
de Souza, Helio Moraes
Borbolla, Jose Rafael
Pasquini, Ricardo
Abstract: Associations between aplastic anemia and numerous drugs, pesticides and chemicals have been reported. However, at least 50% of the etiology of aplastic anemia remains unexplained. This was a case-control, multicenter, multinational study, designed to identify risk factors for agranulocytosis and aplastic anemia. The cases were patients with diagnosis of aplastic anemia confirmed through biopsy or bone marrow aspiration, selected through an active search of clinical laboratories, hematology clinics and medical records. The controls did not have either aplastic anemia or chronic diseases. A total of 224 patients with aplastic anemia were included in the study, each case was paired with four controls, according to sex, age group, and hospital where the case was first seen. Information was collected on demographic data, medical history, laboratory tests, medications, and other potential risk factors prior to diagnosis. The incidence of aplastic anemia was 1.6 cases per million per year. Higher rates of benzene exposure (>= 30 exposures per year) were associated with a greater risk of aplastic anemia (odds ratio, OR: 4.2; 95% confidence interval, CI: 1.82-9.82). Individuals exposed to chloramphenicol in the previous year had an adjusted OR for aplastic anemia of 8.7 (CI: 0.87-87.93) and those exposed to azithromycin had an adjusted OR of 11.02 (CI 1.14-108.02). The incidence of aplastic anemia in Latin America countries is low. Although the research study centers had a high coverage of health services, the underreporting of cases of aplastic anemia in selected regions can be discussed. Frequent exposure to benzene-based products increases the risk for aplastic anemia. Few associations with specific drugs were found, and it is likely that some of these were due to chance alone
Subject: Anemia aplastica
Country: Itália
Editor: Fondazione Ferrata Storti
Rights: Aberto
Identifier DOI: 10.3324/haematol.2008.002642
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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