Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348203
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampZago, Vanessa Helena de Souza-
dc.contributor.authorunicampD'Alexandri, Fabio Luiz-
dc.contributor.authorunicampPanzoldo, Natália Baratella-
dc.contributor.authorunicampSchreiber, Roberto-
dc.contributor.authorunicampParra, Eliane Soler-
dc.contributor.authorunicampBassora, Fernanda Dutra Santiago-
dc.contributor.authorunicampFaria, Eliana Cotta de-
dc.typeArtigopt_BR
dc.titleOxidized low-density lipoproteins and their antibodies : relationships with the reverse cholesterol transport and carotid atherosclerosis in adults without cardiovascular diseasespt_BR
dc.contributor.authorFerreira, Paolla F.C.-
dc.contributor.authorZago, Vanessa H.S.-
dc.contributor.authorD'Alexandri, Fabio L.-
dc.contributor.authorPanzoldo, Natália B.-
dc.contributor.authorGidlund, Magnus A.-
dc.contributor.authorNakamura, Rui T.-
dc.contributor.authorSchreiber, Roberto-
dc.contributor.authorParra, Eliane S.-
dc.contributor.authorSantiago, Fernanda D.-
dc.contributor.authorNakandakare, Edna R.-
dc.contributor.authorQuintão, Eder C.R.-
dc.contributor.authorFaria, Eliana C. de-
dc.subjectArtéria carótidapt_BR
dc.subjectLipasept_BR
dc.subject.otherlanguageCarotid arterypt_BR
dc.subject.otherlanguageLipasept_BR
dc.description.abstractMetabolic predictors and the atherogenicity of oxidized LDL (oxLDL) and the specific antibodies against oxLDL (oxLDL Ab) are unclear and controversial. In 107 adults without atherosclerotic manifestations, we measured oxLDL and oxLDL Ab, and also the activities of CETP, PLTP, lipases and the carotid intima-media thickness (cIMT). Comparisons were performed for the studied parameters between the lowest and the highest tertile of oxLDL and oxLDL Ab, and the relationships between studied variables were evaluated. Subjects with higher oxLDL Ab present reduced hepatic lipase activity and borderline increased cIMT. In the highest oxLDL tertile, besides the higher levels of total cholesterol, LDL-C and apoB100, we found reduced CETP activity and higher cIMT. A significant correlation between oxLDL Ab and cIMT, independent of oxLDL, and a borderline correlation between oxLDL and cIMT independent of oxLDL Ab were found. In the multivariate analysis, apoAI was a significant predictor of oxLDL Ab, in contrast to regulation of oxLDL by apoB100, PLTP and inverse of CETP. In adults without atherosclerotic disease, the metabolic regulation and carotid atherosclerosis of oxLDL Ab and oxLDL groups, characterized a dual trait in oxLDL Ab, as a contributor to carotid atherosclerosis, much less so than oxidized LDL, and with a modest atheroprotective rolept_BR
dc.relation.ispartofClinica chimica actapt_BR
dc.relation.ispartofabbreviationClin chim actapt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2012-
dc.date.monthofcirculationOct.pt_BR
dc.language.isoengpt_BR
dc.description.volume413pt_BR
dc.description.issuenumber19–20pt_BR
dc.description.firstpage1472pt_BR
dc.description.lastpage1478pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0009-8981pt_BR
dc.identifier.eissn1873-3492pt_BR
dc.identifier.doi10.1016/j.cca.2012.05.020pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0009898112002975pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber471380/2008-3pt_BR
dc.description.sponsordocumentnumber2006/60585-9pt_BR
dc.date.available2020-08-28T12:53:36Z-
dc.date.accessioned2020-08-28T12:53:36Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-08-28T12:53:36Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:14:29Z : No. of bitstreams: 1 000307924000009.pdf: 441658 bytes, checksum: 7ae33a62fc629633162e23ea8f8561ad (MD5)en
dc.description.provenanceMade available in DSpace on 2020-08-28T12:53:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348203-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Patologia Clínicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordOxidized LDLpt_BR
dc.subject.keywordAntibodies against oxidizedpt_BR
dc.subject.keywordAntibodies against oxidizedpt_BR
dc.subject.keywordPhospholipid transfer proteinpt_BR
dc.identifier.source000307924000009pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-8930-7556pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-5208-1274pt_BR
dc.type.formArtigopt_BR
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