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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSawaya, Alexandra Christine Helena Frankland-
dc.typeArtigopt_BR
dc.titleAntioxidant, anti-acetylcholinesterase and cytotoxic activities of ethanol extracts of peel, pulp and seeds of exotic Brazilian fruits: Antioxidant, anti-acetylcholinesterase and cytotoxic activities in fruitspt_BR
dc.contributor.authorBazilio Omena, Cristhiane Maria-
dc.contributor.authorValentim, Iara Barros-
dc.contributor.authorGuedes, Glaucevane da S.-
dc.contributor.authorRabelo, Luiza A.-
dc.contributor.authorMano, Camila Marinho-
dc.contributor.authorHenriques Bechara, Etelvino Jose-
dc.contributor.authorSawaya, Alexandra C. H. F.-
dc.contributor.authorSalles Trevisan, Maria Teresa-
dc.contributor.authorda Costa, Joao Gomes-
dc.contributor.authorSilva Ferreira, Roberta Costa-
dc.contributor.authorGoulart Sant'Ana, Antonio Euzebio-
dc.contributor.authorFonseca Goulart, Marilia Oliveira-
dc.subjectFrutas tropicaispt_BR
dc.subject.otherlanguageTropical fruitpt_BR
dc.description.abstractEthanol extracts of powdered genipap (Genipa americana L.), umbu (Spondia tuberosa A.) and siriguela (Spondia purpurea L.) prepared from separate pulp, seeds and peel were investigated for their (i) antioxidant capacity, which was evaluated by various known methods; (ii) acetylcholinesterase (AChE) inhibitory activity; and (iii) cytotoxic effect on corneal epithelial cells of sheep. The highest values of total phenolic content were obtained with peel and seed extracts. Siriguela and umbu (seeds and peel) extracts displayed the highest antioxidant activities. Lipid peroxidation assays using mimetic biomembranes and mouse liver homogenates indicated that genipap pulp is a promising antioxidant. The investigation of phenols and organic acid contents revealed the presence of quercetin, citric and quinic acids, chlorogenic acid derivatives, among others, in several extracts, with the highest amount found in siriguela seeds. Genipap pulp and siriguela seed ethanol extracts presented an AChE inhibition zone similar to that of the positive control, carbachol. AChE inhibition assay with chlorogenic acid, one of the main constituents of siriguela seeds, revealed that this acid showed activity similar to that of the control physostigmine. These data suggest that these extracts are potentially important antioxidant supplements for the everyday human diet, pharmaceutical and cosmetic industriespt_BR
dc.relation.ispartofFood research internationalpt_BR
dc.relation.ispartofabbreviationFood res. int.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2012-
dc.date.monthofcirculationNov.pt_BR
dc.language.isoengpt_BR
dc.description.volume49pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage334pt_BR
dc.description.lastpage344pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0963-9969pt_BR
dc.identifier.eissn1873-7145pt_BR
dc.identifier.doi10.1016/j.foodres.2012.07.010pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0963996912002530pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber2008/58035-6pt_BR
dc.date.available2020-08-27T17:28:29Z-
dc.date.accessioned2020-08-27T17:28:29Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-08-27T17:28:29Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:14:25Z : No. of bitstreams: 1 000311592500043.pdf: 1008241 bytes, checksum: fdc3d5ba7d064af8360c8f603ed2d5dc (MD5)en
dc.description.provenanceMade available in DSpace on 2020-08-27T17:28:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348148-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordTotal phenolic contentpt_BR
dc.subject.keywordFree radical scavenging activitypt_BR
dc.subject.keywordAntioxidant capacitypt_BR
dc.subject.keywordBODIPYpt_BR
dc.subject.keywordAcetylcholinesterase inhibitionpt_BR
dc.identifier.source000311592500043pt_BR
dc.creator.orcid0000-0001-7524-6628pt_BR
dc.type.formArtigopt_BR
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