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|Title:||Antioxidant, anti-acetylcholinesterase and cytotoxic activities of ethanol extracts of peel, pulp and seeds of exotic Brazilian fruits: Antioxidant, anti-acetylcholinesterase and cytotoxic activities in fruits|
|Author:||Bazilio Omena, Cristhiane Maria|
Valentim, Iara Barros
Guedes, Glaucevane da S.
Rabelo, Luiza A.
Mano, Camila Marinho
Henriques Bechara, Etelvino Jose
Sawaya, Alexandra C. H. F.
Salles Trevisan, Maria Teresa
da Costa, Joao Gomes
Silva Ferreira, Roberta Costa
Goulart Sant'Ana, Antonio Euzebio
Fonseca Goulart, Marilia Oliveira
|Abstract:||Ethanol extracts of powdered genipap (Genipa americana L.), umbu (Spondia tuberosa A.) and siriguela (Spondia purpurea L.) prepared from separate pulp, seeds and peel were investigated for their (i) antioxidant capacity, which was evaluated by various known methods; (ii) acetylcholinesterase (AChE) inhibitory activity; and (iii) cytotoxic effect on corneal epithelial cells of sheep. The highest values of total phenolic content were obtained with peel and seed extracts. Siriguela and umbu (seeds and peel) extracts displayed the highest antioxidant activities. Lipid peroxidation assays using mimetic biomembranes and mouse liver homogenates indicated that genipap pulp is a promising antioxidant. The investigation of phenols and organic acid contents revealed the presence of quercetin, citric and quinic acids, chlorogenic acid derivatives, among others, in several extracts, with the highest amount found in siriguela seeds. Genipap pulp and siriguela seed ethanol extracts presented an AChE inhibition zone similar to that of the positive control, carbachol. AChE inhibition assay with chlorogenic acid, one of the main constituents of siriguela seeds, revealed that this acid showed activity similar to that of the control physostigmine. These data suggest that these extracts are potentially important antioxidant supplements for the everyday human diet, pharmaceutical and cosmetic industries|
|Appears in Collections:||IB - Artigos e Outros Documentos|
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