Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348144
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCenteville, Maraisa-
dc.contributor.authorunicampAbramczuk, Beatriz Mariana-
dc.contributor.authorunicampMazzola, Taís Nitsch-
dc.contributor.authorunicampSilva, Marcos Tadeu Nolasco da-
dc.contributor.authorunicampVilela, Maria Marluce dos Santos-
dc.typeArtigopt_BR
dc.titleXLA patients display reduced expansion for BCG cellular immune response and a lower ifn-gamma productionpt_BR
dc.contributor.authorCenteville, M.-
dc.contributor.authorR. D, Vanessa-
dc.contributor.authorAbramczuk, B. M.-
dc.contributor.authorMazzola, T. N.-
dc.contributor.authorVasconcelos, D. M.-
dc.contributor.authorRoxo, P.-
dc.contributor.authorSilva, M. T. N-
dc.contributor.authorVilela, M. M. S.-
dc.subjectPacientespt_BR
dc.subject.otherlanguagePatientspt_BR
dc.description.abstractThe aim of this study was to investigate whether X- Linked Agammaglobulinaemia (XLA) patients with BCG scars can alter the subset composition, activation or function of specific BCG T cells and pro and anti inflammatory cytokines. After, we investigated Mycobacterium bovis bacilli Calmette-Guerin (BCG) vaccination, administered by the intradermic route, the cellular immune response in 14 patients with XLA and compared this to 18 healthy males paired by gender and age. We examined the production of proinflammatory Th1 (IFN-g) and Th2 (IL-4), TNF-a and anti-inflammatory IL-10 cytokines in supernatant of peripheral mononuclear cell cultures in response to live BCG, and PHA to determine specific and non-specific adaptive immune responses. We observed a reduction of the proliferative response to BCG and PHA, as well as a reduction in IFN- γ production in response to BCG. The proportion of blast CD4, CD8 and γδ T cells is preserved (data not shown), indicating that the lymphocyte subpopulations are usually represented, but that the proliferative response is decreased. Furthermore, in vitro T cell activation, in response to live BCG and PHA signals, leads to a lower IFN-g production although the cell culture spontaneously produces normal TNF-a and IL-10. These data agree with results recently described that effector and regulatory B cell subsets modulate the function of T cellspt_BR
dc.relation.ispartofJournal of clinical immunologypt_BR
dc.relation.ispartofabbreviationJ clin immunolpt_BR
dc.publisher.cityNew York, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherSpringerpt_BR
dc.date.issued2012-
dc.language.isoengpt_BR
dc.description.volume32pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage271pt_BR
dc.description.lastpage271pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0271-9142pt_BR
dc.identifier.eissn1573-2592pt_BR
dc.identifier.urlhttps://observatorio.fm.usp.br/handle/OPI/3187pt_BR
dc.date.available2020-08-27T17:00:04Z-
dc.date.accessioned2020-08-27T17:00:04Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-08-27T17:00:04Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-08-27T17:00:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348144-
dc.contributor.departmentDepartamento de Pediatriapt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Pediatriapt_BR
dc.contributor.departmentDepartamento de Pediatriapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordCellular immunept_BR
dc.identifier.source000308728900553pt_BR
dc.creator.orcid0000-0003-0540-738Xpt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0003-4701-7734pt_BR
dc.creator.orcid0000-0001-8342-1959pt_BR
dc.creator.orcid0000-0002-2618-0148pt_BR
dc.type.formArtigopt_BR
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