Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348140
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampErnesto, Aline Santarem-
dc.contributor.authorunicampMorcillo, André Moreno-
dc.contributor.authorunicampVilela, Maria Marluce dos Santos-
dc.contributor.authorunicampSilva, Marcos Tadeu Nolasco da-
dc.typeArtigopt_BR
dc.titleUsefulness of pharmacy dispensing records in the evaluation of adherence to antiretroviral therapy in Brazilian children and adolescentspt_BR
dc.contributor.authorErnesto, Aline Santarem-
dc.contributor.authorLemos, Renata Muller Banzato Pinto de-
dc.contributor.authorHuehara, Maria Ivone-
dc.contributor.authorMorcillo, André Moreno-
dc.contributor.authorVilela, Maria Marluce dos Santos-
dc.contributor.authorSilva, Marcos Tadeu Nolasco da-
dc.subjectImunidadept_BR
dc.subjectAdolescentespt_BR
dc.subject.otherlanguageImmunitypt_BR
dc.subject.otherlanguageAdolescentpt_BR
dc.description.abstractAdherence, which is crucial to the success of antiretroviral therapy (HAART), is currently a major challenge in the care of children and adolescents living with HIV/AIDS. To evaluate the prevalence of nonadherence to HAART using complementary instruments in a cohort of children and adolescents with HIV/AIDS followed in a reference service in Campinas, Brazil. The level of adherence of 108 patients and caregivers was evaluated by an adapted standardized questionnaire and pharmacy dispensing records (PDR). Non-adherence was defined as a drug intake lower than 95% (on 24-hour or seven-day questionnaires), or as an interval of 38 days or more for pharmacy refills. The association between adherence and clinical, immunological, virological, and psychosocial characteristics was assessed by multivariate analysis. Non-adherence prevalence varied from 11.1% (non-adherent in three instruments), 15.8% (24-hour self-report), 27.8% (seven-day self-report), 45.4% (PDR), and 56.3% (at least one of the outcomes). 24-hour and seven-day self-reports, when compared to PDR, showed low sensitivity (29% and 43%, respectively) but high specificity (95% and 85%, respectively). In multivariate analysis, medication intolerance, difficulty of administration by caregiver, HAART intake by the patient, lower socioeconomical class, lack of virological control, missed appointments in the past six months, and lack of religious practice by caregiver were significantly associated with non-adherence. A high prevalence of HAART non-adherence was observed in the study population, and PDR was the most sensitive of the tested instruments. The instruments employed were complementary in the identification of non-adherencept_BR
dc.relation.ispartofThe brazilian journal of infectious diseasespt_BR
dc.relation.ispartofabbreviationBraz. j. infect. dis.pt_BR
dc.publisher.cityBristolpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2012-
dc.date.monthofcirculationJuly/Aug.pt_BR
dc.language.isoengpt_BR
dc.description.volume16pt_BR
dc.description.issuenumber4pt_BR
dc.rightsAbertopt_BR
dc.sourceSCIELOpt_BR
dc.identifier.issn1413-8670pt_BR
dc.identifier.eissn1678-4391pt_BR
dc.identifier.doi10.1016/j.bjid.2012.06.006pt_BR
dc.identifier.urlhttps://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400001pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2009/06948-0pt_BR
dc.date.available2020-08-27T16:43:06Z-
dc.date.accessioned2020-08-27T16:43:06Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-08-27T16:43:06Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:14:24Z : No. of bitstreams: 1 S1413-86702012000400001.pdf: 240265 bytes, checksum: 1ced23e2711516bd426d6ec2e6489da9 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-08-27T16:43:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348140-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Pediatriapt_BR
dc.contributor.departmentDepartamento de Pediatriapt_BR
dc.contributor.departmentDepartamento de Pediatriapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordSyndromept_BR
dc.subject.keywordChildpt_BR
dc.subject.keywordHighly active antiretroviral therapypt_BR
dc.subject.keywordMedication adherencept_BR
dc.identifier.sourceS1413-86702012000400001pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-2088-972Xpt_BR
dc.creator.orcid0000-0002-2618-0148pt_BR
dc.creator.orcid0000-0001-8342-1959pt_BR
dc.type.formArtigo originalpt_BR
dc.description.sponsorNoteThis study was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), scholarship No. 2009/06948-0, and by the Fundo de Apoio ao Ensino, Pesquisa e Extensão (FAEPEX) UNICAMP, grant No. 0449/08pt_BR
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