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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAppenzeller, Simone-
dc.typeArtigopt_BR
dc.titleSeizures in primary antiphospholipid syndrome: the relevance of smoking to strokept_BR
dc.contributor.authorde Carvalho, Jozelio Freire-
dc.contributor.authorPasoto, Sandra Gofinet-
dc.contributor.authorAppenzeller, Simone-
dc.subjectLúpus eritematoso sistêmicopt_BR
dc.subjectEpilepsiapt_BR
dc.subject.otherlanguageLupus erythematosus, Systemicpt_BR
dc.subject.otherlanguageEpilepsypt_BR
dc.description.abstractTo evaluate the frequency of seizures in primary antiphospholipid syndrome (PAPS) and their possible clinical and laboratory associations. Methods. Eighty-eight PAPS patients (Sydney's criteria) were analyzed by a standard interview, physical examination and review of medical charts. Risk factors for seizures, clinical manifestations, associated comorbidities, and antiphospholipid antibodies were evaluated. Results. Nine (10.2%) patients with seizures were identified, 77.8% had convulsions onset after PAPS diagnosis. Mean age, gender, and race were comparable in groups with or without seizures. Interestingly, a higher frequency of current smoking (44.4 versus 10.1%, P = 0.019) was observed in the first group. Stroke, Sneddon's syndrome, and livedo reticularis were more frequent in PAPS patients with seizures than those without seizures, although not statistically significant (P > 0.05). Comparison between patients with seizures onset after PAPS diagnosis (n = 7) and those without convulsions (n = 79) demonstrated a higher frequency of current smoking (42.9 versus 10%, P = 0.042) and stroke in the first group (71.4 versus 30.4%, P = 0.041). Regression analysis confirmed that smoking (P = 0.030) and stroke (P = 0.042) were independently associated to seizures. Conclusion. About 10.2% of PAPS patients had convulsions, predominantly after PAPS diagnosis, and seizures were associated to current smoking and strokept_BR
dc.relation.ispartofJournal of immunology researchpt_BR
dc.relation.ispartofabbreviationJ. immunol. res.pt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherHindawipt_BR
dc.date.issued2012-
dc.language.isoengpt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn2314-8861pt_BR
dc.identifier.eissn2314-7156pt_BR
dc.identifier.doi10.1155/2012/981519pt_BR
dc.identifier.urlhttps://www.hindawi.com/journals/jir/2012/981519/pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber300665/2009-1; 2009/06049-6pt_BR
dc.description.sponsordocumentnumber2008/02917-0 2010/10013-4pt_BR
dc.date.available2020-08-25T19:04:35Z-
dc.date.accessioned2020-08-25T19:04:35Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-08-25T19:04:35Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:14:09Z : No. of bitstreams: 1 000302596000001.pdf: 168100 bytes, checksum: 277e16a82eed4c9dd9e010ec2edb9b60 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-08-25T19:04:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/347987-
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000302596000001pt_BR
dc.creator.orcid0000-0001-5075-4474pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid981519pt_BR
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