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http://repositorio.unicamp.br/jspui/handle/REPOSIP/347987
Type: | Artigo |
Title: | Seizures in primary antiphospholipid syndrome: the relevance of smoking to stroke |
Author: | de Carvalho, Jozelio Freire Pasoto, Sandra Gofinet Appenzeller, Simone |
Abstract: | To evaluate the frequency of seizures in primary antiphospholipid syndrome (PAPS) and their possible clinical and laboratory associations. Methods. Eighty-eight PAPS patients (Sydney's criteria) were analyzed by a standard interview, physical examination and review of medical charts. Risk factors for seizures, clinical manifestations, associated comorbidities, and antiphospholipid antibodies were evaluated. Results. Nine (10.2%) patients with seizures were identified, 77.8% had convulsions onset after PAPS diagnosis. Mean age, gender, and race were comparable in groups with or without seizures. Interestingly, a higher frequency of current smoking (44.4 versus 10.1%, P = 0.019) was observed in the first group. Stroke, Sneddon's syndrome, and livedo reticularis were more frequent in PAPS patients with seizures than those without seizures, although not statistically significant (P > 0.05). Comparison between patients with seizures onset after PAPS diagnosis (n = 7) and those without convulsions (n = 79) demonstrated a higher frequency of current smoking (42.9 versus 10%, P = 0.042) and stroke in the first group (71.4 versus 30.4%, P = 0.041). Regression analysis confirmed that smoking (P = 0.030) and stroke (P = 0.042) were independently associated to seizures. Conclusion. About 10.2% of PAPS patients had convulsions, predominantly after PAPS diagnosis, and seizures were associated to current smoking and stroke |
Subject: | Lúpus eritematoso sistêmico Epilepsia |
Country: | Reino Unido |
Editor: | Hindawi |
Rights: | Aberto |
Identifier DOI: | 10.1155/2012/981519 |
Address: | https://www.hindawi.com/journals/jir/2012/981519/ |
Date Issue: | 2012 |
Appears in Collections: | FCM - Artigos e Outros Documentos |
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000302596000001.pdf | 164.16 kB | Adobe PDF | View/Open |
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