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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFarias, Alessandro dos Santos-
dc.contributor.authorunicampPradella, Fernando-
dc.contributor.authorunicampMoraes, Adriel dos Santos-
dc.contributor.authorunicampFacchini, Gustavo-
dc.contributor.authorunicampNovello, Jose Camillo-
dc.contributor.authorunicampSantos, Leonilda Maria Barbosa dos-
dc.typeArtigopt_BR
dc.titleProteome analysis of spinal cord during the clinical course of monophasic experimental autoimmune encephalomyelitispt_BR
dc.contributor.authorFarias, Alessandro S.-
dc.contributor.authorMartins-de-Souza, Daniel-
dc.contributor.authorGuimaraes, Leandro-
dc.contributor.authorPradella, Fernando-
dc.contributor.authorMoraes, Adriel S.-
dc.contributor.authorFacchini, Gustavo-
dc.contributor.authorNovello, Jose Camillo-
dc.contributor.authorSantos, Leonilda M. B.-
dc.subjectEspectrometria de massapt_BR
dc.subject.otherlanguageMass spectrometrypt_BR
dc.description.abstractThe induction of autoimmune encephalomyelitis (EAE) in Lewis rats results in a period of exacerbation followed by complete recovery. Therefore, this model is widely used for studying the evolution of multiple sclerosis. In the present investigation, differentially expressed proteins in the spinal cord of Lewis rats during the evolution of EAE were assessed using the combination of 2DE and MALDI‐TOF MS. The majority of the differentially expressed proteins were identified during the acute phase of EAE, in relation to naïve control animals. On the other hand, recovered rats presented a similar protein expression pattern in comparison with the naïve ones. This observation can be explained, at least in part, by the intense catabolism existent in acute phase due to nervous tissue damage. In recovered rats, we have described the upregulation of proteins that are apparently involved in the recovery of damaged tissue, such as light and medium neurofilaments, glial fibrillary acidic protein, tubulins subunits, and quaking protein. These proteins are involved mainly in cell growth, myelination, and remyelination as well as in astrocyte and oligodendrocyte maturation. The present study has demonstrated that the inflammatory response, characterized by an increase of the proliferative response and infiltration of autoreactive T lymphocytes in the central nervous system, occurs simultaneously with neurodegenerationpt_BR
dc.relation.ispartofProteomicspt_BR
dc.publisher.cityWeinheimpt_BR
dc.publisher.countryAlemanhapt_BR
dc.publisherJohn Wiley & Sonspt_BR
dc.date.issued2012-
dc.date.monthofcirculationAug.pt_BR
dc.language.isoengpt_BR
dc.description.volume12pt_BR
dc.description.issuenumber17pt_BR
dc.description.firstpage2656pt_BR
dc.description.lastpage2662pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1615-9853pt_BR
dc.identifier.eissn1615-9861pt_BR
dc.identifier.doi10.1002/pmic.201200044pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/pmic.201200044pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2009/15620-9; 2009/18227-6; 2011/18728-5pt_BR
dc.date.available2020-08-25T18:17:34Z-
dc.date.accessioned2020-08-25T18:17:34Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-08-25T18:17:34Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:14:09Z : No. of bitstreams: 1 000308098700007.pdf: 400581 bytes, checksum: e60ae5133c5c6b0218a695a101df3cce (MD5)en
dc.description.provenanceMade available in DSpace on 2020-08-25T18:17:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/347977-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.departmentDepartamento de Genética, Evolução e Bioagentespt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordBiomedicine Inflammationpt_BR
dc.subject.keywordNeurodegenerationpt_BR
dc.subject.keywordProtein expressionpt_BR
dc.identifier.source000308098700007pt_BR
dc.creator.orcid0000-0001-6759-1819pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-9365-573Xpt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-3600-9205pt_BR
dc.type.formComunicaçãopt_BR
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