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Type: Artigo
Title: On the pathogenesis of Plasmodium vivax malaria: Perspectives from the Brazilian field
Author: Costa, Fabio T. M.
Lopes, Stefanie C. P.
Albrecht, Letusa
Ataide, Ricardo
Siqueira, Andre M.
Souza, Rodrigo M.
Russell, Bruce
Renia, Laurent
Marinho, Claudio R. F.
Lacerda, Marcus V. G.
Abstract: Life-threatening Plasmodium vivax malaria cases, while uncommon, have been reported since the early 20th century. Unfortunately, the pathogenesis of these severe vivax malaria cases is still poorly understood. In Brazil, the proportion of vivax malaria cases has been steadily increasing, as have the number of cases presenting serious clinical complications. The most frequent syndromes associated with severe vivax malaria in Brazil are severe anaemia and acute respiratory distress. Additionally, P. vivax infection may also result in complications associated with pregnancy. Here, we review the latest findings on severe vivax malaria in Brazil. We also discuss how the development of targeted field research infrastructure in Brazil is providing clinical and ex vivo experimental data that benefits local and international efforts to understand the pathogenesis of P. vivax
Subject: Malaria
Country: Reino Unido
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.ijpara.2012.08.007
Date Issue: 2012
Appears in Collections:IB - Artigos e Outros Documentos

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