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Type: Artigo
Title: Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy
Author: Amaral, L M
Palei, A C T
Sandrim, V C
Luizon, M R
Cavalli, R C
Duarte, G
Tanus-Santos, J E
Abstract: Increased expression and activity of inducible nitric oxide synthase (iNOS) may contribute to the pathogenesis of pre-eclampsia (PE) and gestational hypertension (GH). However, no previous study has examined whether genetic polymorphisms in the iNOS gene are associated with PE or GH. We examined whether two functional, clinically relevant iNOS genetic polymorphisms (the C−1026A polymorphism, rs2779249, in the promoter region, and the G2087A polymorphism, rs2297518, in exon 16) are associated with GH or with PE. We studied 565 pregnant women: 212 healthy pregnant (HP), 166 pregnant with GH and 187 pregnant with PE. Genotypes were determined by real-time PCR, using the Taqman allele discrimination assay. The PHASE 2.1 program was used to estimate haplotype distributions in the three study groups. We found no significant association between the C−1026A polymorphism and PE or GH (P>0.05). However, we found the GA genotype and the A allele for the G2087A polymorphism at higher frequency in PE, but not in GH, compared with HP (P<0.05). The haplotype analysis showed no significant intergroup differences (P>0.05). These findings suggest that iNOS genetic variants may affect the susceptibility to PE, but not to GH
Subject: Polimorfismo (Genética)
Country: Reino Unido
Editor: Nature Publishing Group
Rights: Fechado
Identifier DOI: 10.1038/jhh.2011.65
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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