Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/347837
Type: Artigo
Title: Neurosyphilis in HIV-infected patients: clinical manifestations, serum venereal disease research laboratory titers, and associated factors to symptomatic neurosyphilis
Author: Poliseli, Rodolfo
Vidal, Jose E.
Oliveira, Augusto C. Penalva De
Hernandez, Adrian V.
Abstract: To describe clinical and laboratory features of human immunodeficiency infection (HIV)-infected patients with neurosyphilis.Study Design: Retrospective study of 27 consecutive cases of HIV-infected patients with a positive Venereal Disease Research Laboratory (VDRL) in cerebrospinal fluid (CSF). Results: Median of age was 36 years and 89% were men. Ten (37%) patients had previous nonneurologic syphilis treatment. At the time of neurosyphilis diagnosis, 10 (37%) patients had early syphilis, and 6 of them were neurologically asymptomatic. Nine (33%) patients had symptomatic neurosyphilis. Twenty-six (96%) patients were classified with early neurosyphilis. The medians of serum VDRL and CD4+ T cell counts were 1:128 and 182 cell/μL, respectively. Twenty five (93%) patients presented serum VDRL titers ≥1:16. Five of 6 patients with early syphilis and asymptomatic neurosyphilis, presented serum VDRL ≥1:16. Symptomatic patients showed lower CD4+ T cell counts (59 cell/μL vs. 208 cell/μL, P = 0.03) and higher protein concentration on CSF (118 mg/dL vs. 39 mg/dL, P <0.001) than asymptomatic patients. Conclusions: Most patients had early and asymptomatic neurosyphilis, and more than one third had early syphilis. Patients with symptomatic neurosyphilis showed lower CD4+ T cell counts and higher protein concentration on CSF than those asymptomatic. Most patients had serum VDRL titers ≥1:16, regardless of syphilis stage
Subject: HIV (Vírus)
Country: Estados Unidos
Editor: Lippincott Williams & Wilkins
Rights: Fechado
Identifier DOI: 10.1097/OLQ.0b013e3181623853
Address: https://journals.lww.com/stdjournal/Fulltext/2008/05000/Neurosyphilis_in_HIV_Infected_Patients__Clinical.1.aspx
Date Issue: 2008
Appears in Collections:HC - Artigos e Outros Documentos

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