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Type: Artigo
Title: Caracterização físico-química de complexo de inclusão entre hidroximetilnitrofurazona e hidroxipropil-b-ciclodextrina
Title Alternative: Physico-chemical characterization of inclusion complex between hydroxymethylnitrofurazone and hydroxypropyl-b-cyclodextrin
Author: Renato Grillo
Nathalie F. S. de Melo
Leonardo Fernandes Fraceto
Charles L. Brito
Gustavo H. G. Trossini
Carla M. S. Menezes
Elizabeth Igne Ferreira
Carolina Morales Moraes
Abstract: Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-b-cyclodextrin (HP-b-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-b-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (DGº= 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment
Subject: Ciclodextrinas
Country: Brasil
Editor: Sociedade Brasileira de Química
Rights: Aberto
Identifier DOI: 10.1590/S0100-40422008000200019
Date Issue: 2008
Appears in Collections:IB - Artigos e Outros Documentos

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