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Type: Artigo
Title: A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
Author: Vita-Marques, Aline Maria de
Lira, Simone P.
Berlinck, Roberto G. S.
Seleghim, Mirna H. R.
Sponchiado, Sandra R. P.
Tauk-Tornisielo, Sâmia M.
Barata, Margarida
Pessoa, Claudia
Moraes, Manoel O. de
Cavalcanti, Bruno Coêlho
Nascimento, Gislene G. F.
Souza, Ana O. de
Galetti, Fabio C. S.
SilvaI, Célio L.
Silva, Marcio
Pimenta, Eli F.
Thiemann, Otavio
Passarini, Michel R. Z.
Sette, Lara D.
Abstract: Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and 1H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites
Subject: Fungos derivados marinhos
Country: Brasil
Editor: Sociedade Brasileira de Química
Rights: Aberto
Identifier DOI: 10.1590/S0100-40422008000500030
Date Issue: 2008
Appears in Collections:CPQBA - Artigos e Outros Documentos

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