Please use this identifier to cite or link to this item:
|Title:||Constituents and antiproliferative activity of extracts from leaves of croton macrobothrys|
|Author:||Motta, Lucimar B.|
Furlan, Cláudia M.
Santos, Deborah Y. A. C.
Salatino, Maria L. F.
Duarte-Almeida, Joaquim M.
Carvalho, João E. de
Ruiz, Ana Lúcia T. G.
|Abstract:||Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes|
|Appears in Collections:||CPQBA - Artigos e Outros Documentos|
Files in This Item:
|S0102-695X2011000600006.pdf||374.15 kB||Adobe PDF||View/Open|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.