Please use this identifier to cite or link to this item:
|Title:||Use of experimental design for the optimization of the production of new secondary metabolites by two penicillium species|
|Author:||Pimenta, Eli F.|
Vita-Marques, Aline M.
Seleghim, Mirna H. R.
Sette, Lara D.
Ferreira, Antonio G.
Williams, David E.
Patrick, Brian O.
Dalisay, Doralyn S.
Andersen, Raymond J.
Berlinck, Roberto G. S.
|Abstract:||A fractional factorial design approach has been used to enhance secondary metabolite production by two Penicillium strains. The method was initially used to improve the production of bioactive extracts as a whole and subsequently to optimize the production of particular bioactive metabolites. Enhancements of over 500% in secondary metabolite production were observed for both P. oxalicum and P. citrinum. Two new alkaloids, citrinalins A (5) and B (6), were isolated and identified from P. citrinum cultures optimized for production of minor metabolites|
|Editor:||American Chemical Society|
|Appears in Collections:||CPQBA - Artigos e Outros Documentos|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.