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Type: Artigo
Title: Use of experimental design for the optimization of the production of new secondary metabolites by two penicillium species
Author: Pimenta, Eli F.
Vita-Marques, Aline M.
Tininis, Aristeu
Seleghim, Mirna H. R.
Sette, Lara D.
Veloso, Katyuscya
Ferreira, Antonio G.
Williams, David E.
Patrick, Brian O.
Dalisay, Doralyn S.
Andersen, Raymond J.
Berlinck, Roberto G. S.
Abstract: A fractional factorial design approach has been used to enhance secondary metabolite production by two Penicillium strains. The method was initially used to improve the production of bioactive extracts as a whole and subsequently to optimize the production of particular bioactive metabolites. Enhancements of over 500% in secondary metabolite production were observed for both P. oxalicum and P. citrinum. Two new alkaloids, citrinalins A (5) and B (6), were isolated and identified from P. citrinum cultures optimized for production of minor metabolites
Subject: Penicillium
Country: Estados Unidos
Editor: American Chemical Society
Rights: Fechado
Identifier DOI: 10.1021/np100470h
Date Issue: 2010
Appears in Collections:CPQBA - Artigos e Outros Documentos

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