Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/347428
Type: Artigo
Title: Liposome‐loaded cell backpacks
Author: Polak, Roberta
Lim, Rosanna M.
Beppu, Marisa M.
Pitombo, Ronaldo N. M.
Cohen, Robert E.
Rubner, Michael F.
Abstract: Cell backpacks, or micron‐scale patches of a few hundred nanometers in thickness fabricated by layer‐by‐layer (LbL) assembly, are potentially useful vehicles for targeted drug delivery on the cellular level. In this work, echogenic liposomes (ELIPs) containing the anticancer drug doxorubicin (DOX) are embedded into backpacks through electrostatic interactions and LbL assembly. Poly(allylamine hydrochloride)/poly(acrylic acid) (PAH/PAA)n, and poly(diallyldimethylammonium chloride)/poly(styrene sulfonate) (PDAC/SPS)n film systems show the greatest ELIP incorporation of the films studied while maintaining the structural integrity of the vesicles. The use of ELIPs for drug encapsulation into backpacks facilitates up to three times greater DOX loading compared to backpacks without ELIPs. Cytotoxicity studies reveal that monocyte backpack conjugates remain viable even after 72 h, demonstrating promise as drug delivery vehicles. Because artificial vesicles can load many different types of drugs, ELIP containing backpacks offer a unique versatility for broadening the range of possible applications for cell backpacks
Subject: Lipossomos
Country: Alemanha
Editor: John Wiley & Sons
Rights: Fechado
Identifier DOI: 10.1002/adhm.201500604
Address: https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.201500604
Date Issue: 2015
Appears in Collections:FEQ - Artigos e Outros Documentos

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