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http://repositorio.unicamp.br/jspui/handle/REPOSIP/346743
Type: | Artigo |
Title: | Antimicrobial activity and acute toxicity of ozonated lomefloxacin solution |
Author: | Oliveira, Amanda Marchi Duarte de Maniero, Milena Guedes Rodrigues-Silva, Caio Guimarães, José Roberto |
Abstract: | Lomefloxacin (LOM) is a synthetic antimicrobial from the fluoroquinolone family (FQ) used as a veterinary and human drug. Once in the environment, LOM may pose a risk to aquatic and terrestrial microorganisms due to its antimicrobial activity. This study evaluated the effect of ozonation of LOM (500 μg L−1), the residual antimicrobial activity against Escherichia coli and acute toxicity against Vibrio fischeri. In addition, degradation products were investigated by UHPLC-MS/MS and proposed. Ozonation was carried out varying the applied ozone dose from 0 to 54.0 mg L−1 O3 and pH values of 3, 7, and 11. Ozonation was most efficient at pH 11 and led to 92.8% abatement of LOM in a 9-min reaction time (54.0 mg L−1 O3 applied ozone dose). Ozonation at pH 3 was able to degrade 80.4% of LOM. At pH 7, 74.3% of LOM was degraded. Although the LOM concentration and the antimicrobial activity of the solution dropped as ozone dose increased (antimicrobial activity reduction of 95% at pH 11), toxicity to V. fischeri increased for pH 7 and 11 (i.e., 65% at pH 7 and 75% at pH 11). The reduction in antimicrobial activity may be related to the oxidation of piperazinyl and the quinolone moiety. The formation of intermediates depended on the oxidant (hydroxyl radicals or/and molecular O3) that acted the most in the process |
Subject: | Atividade antimicrobiana Toxicidade aguda |
Country: | Alemanha |
Editor: | Springer |
Rights: | Fechado |
Identifier DOI: | 10.1007/s11356-016-8319-0 |
Address: | https://link.springer.com/article/10.1007/s11356-016-8319-0 |
Date Issue: | 2017 |
Appears in Collections: | FEC - Artigos e Outros Documentos |
Files in This Item:
File | Description | Size | Format | |
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000399163700030.pdf | 872.9 kB | Adobe PDF | View/Open |
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