Please use this identifier to cite or link to this item:
Type: Artigo
Title: Fibrin network architectures in pure platelet-rich plasma as characterized by fiber radius and correlated with clotting time
Author: Perez, Amanda G. M.
Rodrigues, Ana A.
Luzo, Angela C. M.
Lana, José F. S. D.
Belangero, William D.
Santana, Maria H. A.
Abstract: Fibrin networks are obtained through activation of platelet-rich plasma (PRP) for use in tissue regeneration. The importance of fibrin networks relies on mediation of release of growth factors, proliferation of tissue cells and rheological properties of the fibrin gels. Activation of PRP usually involves the decomposition of fibrinogen by agonists, in a wide range of concentrations. Therefore fibrin networks with a large structural diversity are formed, making comparative evaluations difficult. In order to standardize the fibrin networks, we used the statistical techniques central composite rotatable design and response-surface analysis, to correlate the radius of the fibers with the ratios between the agonists (autologous serum/calcium chloride) and agonist/PRP. From an individual and interactive analysis of the variables, architectures characterized by thick, medium and thin fibers were delineated on the response-surface. Furthermore, the architectures were correlated with coagulation time. This approach is valuable for standardizing the PRP preparation for clinical applications
Subject: Fibrinogênio
Country: Estados Unidos
Editor: Springer
Rights: Fechado
Identifier DOI: 10.1007/s10856-014-5235-z
Date Issue: 2014
Appears in Collections:FCM - Artigos e Outros Documentos
FEQ - Artigos e Outros Documentos
HEMO - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000339875800012.pdf1.81 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.