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Type: Artigo
Title: Evaluation of silica nanoparticle colloidal stability with a fiber optic quasi-elastic light scattering sensor
Author: Soares, Marco César Prado
Gomes, Matheus Kauê
Schenkel, Egont Alexandre
Rodrigues, Matheus dos Santos
Suzuki, Carlos Kenichi
la Torre, Lucimara Gaziola de
Fujiwara, Eric
Abstract: Colloidal silica is an important biocompatible, inert and non-toxic material for imaging, therapy, and drug delivery biomedical applications. In this context, the evaluation of colloidal suspensions and their stabilities by a Fiber Optic Quasi-Elastic Light Scattering sensor is proposed. Two different silica nanoparticles were prepared and characterized by scanning electron microscopy and X-ray diffraction, being completely amorphous, with mean diameters of 125 and 159 nm and average specific weight of 1.94 The nanoparticles were dispersed in deionized water in different concentrations ranging from 0 to 2% (m/m), resulting in suspensions with mean kinematic viscosity of 0.009157 cm².s-1. The sensor showed different sensitivities regarding concentrations and diameters, with an increase in the light intensity dispersion caused by the scattering. A decreasing tendency of the decay rate of the autocorrelation function of the light intensity signal was verified with the variation of pH, and this decay rate also showed an abrupt decrease with the enhancement of the ionic strength, detecting the limits of the colloidal stability. This work presents a simple and reliable methodology for the colloidal assessment in a low-cost and minimally invasive way, easily extendable for different chemical and biological systems
Subject: Tecnologia de fibra óptica
Country: Alemanha
Editor: Springer
Rights: Aberto
Identifier DOI: 10.1590/0104-6632.20190364s20190042
Date Issue: 2019
Appears in Collections:FEM - Artigos e Outros Documentos

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