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Type: Artigo
Title: Effects of diffusion and mixing pattern on microfluidic-assisted synthesis of chitosan/ATP nanoparticles
Author: Pessoa, Amanda C. S. N.
Sipoli, Caroline C.
de la Torre, Lucimara G.
Abstract: Chitosan (CHI) nanoparticles present promising applications in pharmaceutical and biomedical fields, including drug and gene delivery. Among different approaches, microfluidics emerges as a resourceful tool for nanoparticle production in low-cost, reproducible processes with predictable fluid dynamics. However, microfluidic-assisted synthesis of CHI nanoparticles has not been widely explored in the literature. In this context, we systematically investigated different process parameters that influence the synthesis of CHI/ATP nanoparticles. We highlight the effects and limitations of diffusion and distinct mixing patterns developed through the microchannels on the final physicochemical characteristics of CHI/ATP nanoparticles produced. To address these hurdles, here we describe a simple, feasible, and reproducible method for the production of CHI/ATP nanoparticles. This strategy enables the development of a continuous and homogeneous production process for CHI nanoparticles to be applied in the most varied fields of research
Subject: Quitosana
Country: Reino Unido
Editor: Royal Society of Chemistry
Rights: Fechado
Identifier DOI: 10.1039/c7lc00291b
Date Issue: 2017
Appears in Collections:FEQ - Artigos e Outros Documentos

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