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Type: Artigo de periódico
Title: Characterization of the physical and mechanical properties of femoral bone defects filled with polyanionic collagen scaffolds in ovariectomized rats
Author: Cunha, Marcelo Rodrigues
Santos Jr, Arnaldo Rodrigues
Petinari, Leandro
Goissis, Gilberto
Nonaka, Keico Okino
Wang, Charles Chenwei
Genari, Selma Candelária
Abstract: The aim of this study was to evaluate the effect of scaffolds native or polyanionic collagen matrix (submitted to alkaline treatment for 48 or 96 hours, PCM48 or PCM96, respectively) on the repair of osteoporosis bone fractures resulting from the gonadal hormone alterations caused by ovariectomy in rats undergoing hormone replacement therapy. The physical and mechanical characteristics of bone were analyzed. Macroscopic analysis revealed the absence of pathological alterations in the implanted areas. The percent mineral matter and bone mineral density of the femurs were lower in ovariectomized rats. The mechanical strength of newly formed bone was greater in the area receiving the PCM96 scaffolds compared to the area implanted with the native scaffolds. The PCM96 scaffold is the best choice for bone repair in animals with hormone deficiency since it promotes faster bone growth and good mechanical strength.
Subject: bone healing
hormone deficiency
polyanionic collagen
Editor: ABM, ABC, ABPol
Rights: aberto
Identifier DOI: 10.1590/S1516-14392010000200019
Date Issue: 1-Jun-2010
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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