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Type: Artigo
Title: A novel Triclosan Methacrylate-based composite reduces the virulence of Streptococcus mutans biofilm
Author: Araújo, Isaac Jordão de Souza
Paula, Andréia Bolzan de
Alonso, Roberta Caroline Bruschi
Taparelli, Jesus Roberto
Mei, Lúcia Helena Innocentini
Stipp, Rafael Nóbrega
Puppin-Rontani, Regina Maria
Abstract: The use of antimicrobial monomers, linked to the polymer chain of resin composites, is an interesting approach to circumvent the effects of bacteria on the dental and material surfaces. In addition, it can likely reduce the incidence of recurrent caries lesions. The aim of this study was to evaluate the effects of a novel Triclosan Methacrylate (TM) monomer, which was developed and incorporated into an experimental resin composite, on Streptococcus mutans (S. mutans) biofilms, focusing on the analyses of vicR, gtfD, gtfC, covR, and gbpB gene expression, cell viability and biofilm characteristics. The contact time between TM-composite and S. mutans down-regulated the gbpB and covR and up-regulated the gtfC gene expression, reduced cell viability and significantly decreased parameters of the structure and characteristics of S. mutans biofilm virulence. The presence of Triclosan Methacrylate monomer causes harmful effects at molecular and cellular levels in S. mutans, implying a reduction in the virulence of those microorganisms
Subject: Triclosan
Country: Estados Unidos
Editor: Public Library of Science
Rights: Aberto
Identifier DOI: 10.1371/journal.pone.0195244
Date Issue: 2018
Appears in Collections:FEQ - Artigos e Outros Documentos

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