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Type: Artigo
Title: Evaluation of cytotoxicity of nanolipid carriers with structured buriti oil in the caco-2 and hepG2 cell lines
Author: Reis, Lívia Viana de Castro
Leão, Karina Magna Macena
Ribeiro, Ana Paula Badan
Jesus, Marcelo Bispo de
Macedo, Gabriela Alves
Macedo, Juliana Alves
Abstract: Buriti oil is rich in monounsaturated fatty acids, carotenoids and tocopherols and it is used for the treatment of various diseases. One strategy to restructure the triglycerides is enzymatic interesterification and nanocarriers have been employed to improve the solubility, bioavailability and stability of active compounds. This work aims to investigate the in vitro cytotoxicity of this structured oil in nanoemulsions and nanostructured lipid carriers to expand the applicability of the crude oil. None of the samples had a cytotoxic effect on Caco-2 and HepG2 cell lines at the concentrations tested. Structured lipids acted protecting against oxidative stress and lipid peroxidation. Additionally, no consumption of glutathione has been observed in both cells, and the compounds present in buriti oil are possibly acting as antioxidants. Thus, nanoparticles prepared with interesterified buriti oil had low cytotoxicity and high oxidative stability, with great potential for future applications
Subject: Citotoxicidade
Country: Alemanha
Editor: Springer
Rights: Fechado
Identifier DOI: 10.1007/s00449-020-02308-6
Date Issue: 2020
Appears in Collections:IB - Artigos e Outros Documentos
FEA - Artigos e Outros Documentos

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