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Type: Artigo
Title: Evaluation of the antihyperten si ve propertiesof yellow passion fruit pulp (passiflora edulissims f. flavicarpa deg.) in spontaneouslyhypertensive rats
Author: Konta, Eliziane Mieko
Almeida, Mara Ribeiro
Amaral, Cátia Lira do
Darin, Joana Darc Castania
Rosso, Veridiana V. de
Mercadante, Adriana Zerlotti
Antunes, Lusânia Maria Greggi
Bianchi, Maria Lourdes Pires
Abstract: Various species of the genus Passiflora have been extensively used in traditional medicine as sedatives, anxiolytics, diuretics and analgesics. In the present study, after the identification and quantification of phytochemical compounds from yellow passion fruit pulp by liquid chromatography‐photodiode array‐mass spectrometry (HPLC‐PDA‐MS/MS), its antihypertensive effect was investigated on spontaneously hypertensive rats. Additionally, the renal function, evaluated by kidney/body weight, serum creatinine, proteinuria, urinary flow, reduced glutathione (GSH) levels and thiobarbituric acid‐reactive substances (TBARS) and mutagenicity in bone marrow cells were assessed to evaluate the safety of passion fruit consumption. Yellow passion fruit pulp (5, 6 or 8 g/kg b.w.) was administered by gavage once a day for 5 consecutive days. HLPC‐PDA‐MS/MS analysis revealed that yellow passion fruit pulp contains phenolic compounds, ascorbic acid, carotenoids and flavonoids. The highest dose of passion fruit pulp significantly reduced the systolic blood pressure, increased the GSH levels and decreased TBARS. There were no changes in renal function parameters or the frequency of micronuclei in bone marrow cells. In conclusion, the antihypertensive effect of yellow passion fruit pulp, at least in part, might be due to the enhancement of the antioxidant status. The exact mechanisms responsible by this effect need further investigation
Subject: Maracujá
Country: Reino Unido
Editor: John Wiley & Sons
Rights: Fechado
Identifier DOI: 10.1002/ptr.4949
Date Issue: 2014
Appears in Collections:FEA - Artigos e Outros Documentos

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