Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/344673
Type: Artigo
Title: Drug abusers have impaired cerebral oxygenation and cognition during exercise
Author: Costa, Kell Grandjean da
Rachetti, Vanessa Soares
Silva, Weslley Quirino Alves da
Cabral, Daniel Aranha Rego
Machado, Daniel Gomes da Silva
Costa, Eduardo Caldas
Forti, Rodrigo Menezes
Mesquita, Rickson Coelho
Elsangedy, Hassan Mohamed
Okano, Alexandre Hideki
Fontes, Eduardo Bodnariuc
Abstract: Background: Individuals with Substance Use Disorder (SUD) have lower baseline metabolic activity of the prefrontal cortex (PFC) associated with impairment of cognitive functions in decisionmaking and inhibitory control. Aerobic exercise has shown to improve PFC function and cognitive performance, however, its effects on SUD individuals remain unclear. Purpose: To verify the cognitive performance and oxygenation of the PFC during an incremental exercise in SUD individuals. Methods: Fourteen individuals under SUD treatment performed a maximum graded exercise test on a cycle ergometer with continuous measurements of oxygen consumption, PFC oxygenation, and inhibitory control (Stroop test) every two minutes of exercise at different intensities. Fifteen non-SUD individuals performed the same protocol and were used as control group. Results: Exercise increased oxyhemoglobin (O(2)Hb) and total hemoglobin (tHb) by 9% and 7%, respectively. However, when compared to a non-SUD group, this increase was lower at high intensities (p< 0.001), and the inhibitory cognitive control was lower at rest and during exercise (p< 0.007). In addition, PFC hemodynamics during exercise was inversely correlated with inhibitory cognitive performance (reaction time) (r = -0.62, p = 0.001), and a lower craving perception for the specific abused substance (p = 0.0189) was reported immediately after exercise. Conclusion: Despite SUD individuals having their PFC cerebral oxygenation increased during exercise, they presented lower cognition and oxygenation when compared to controls, especially at elevated intensities. These results may reinforce the role of exercise as an adjuvant treatment to improve PFC function and cognitive control in individuals with SUD.
Subject: Atividade física
Hemodinâmica
Circulação cerebral
Consumo de oxigênio
Physical activity
Hemodynamics
Cerebral circulation
Oxygen consumption
Country: Estados Unidos
Editor: Public Library of Science
Rights: aberto
Identifier DOI: 10.1371/journal.pone.0188030
Address: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188030
Date Issue: 2017
Appears in Collections:IFGW - Artigos e Outros Documentos

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