Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/344303
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSetti, Rafaela Ferreira-
dc.contributor.authorunicampRosa, Paulo de Tarso Vieira e-
dc.contributor.authorunicampMoraes, Angela Maria-
dc.typeArtigopt_BR
dc.titleProperties of PLA/PCL particles as vehicles for oral delivery of the androgen hormone 17α-methyltestosteronept_BR
dc.contributor.authorSacchetin, Priscila Soares Costa-
dc.contributor.authorSetti, Rafaela Ferreira-
dc.contributor.authorRosa, Paulo de Tarso Vieira e-
dc.contributor.authorMoraes, Ângela Maria-
dc.subjectPoliácido láticopt_BR
dc.subject.otherlanguagePolylactic acidpt_BR
dc.description.abstractThe aim of this study was to produce PLA (poly(lactic acid)) and PCL (polycaprolactone) oral carriers through the precipitation of the polymer solutions using supercritical CO2 as an antisolvent for the controlled release of the hydrophobic model drug 17α-methyltestosterone (MT). Such drug is a steroidal hormone used orally to develop and sustain primary and secondary male sex characteristics, e.g. for female Nile tilapia sex reversal in aquaculture. The influence of hormone, PLA and PCL concentrations on particle formation was analyzed, showing that high PCL concentrations produced particles with rougher surfaces and greater mean diameters. The incorporation efficiency of MT ranged from 20 to 51%, and its addition resulted in increases in particle mean diameter from 23 to 54 μm. Aggregation was observed for particles incorporating or not MT and high concentrations of MT led to the formation of more amorphous structures, changing the thermal behavior of the particles. The exposure of the PLA/PCL particles to pH conditions simulating gastrointestinal fish conditions showed that hormone release fraction at acidic pH ranged from 8 to 63% (over 2 h), while in the basic pH the proportion released varied from 23 to 60% (over 10 h), reaching levels adequate for the desired in vivo activitypt_BR
dc.relation.ispartofMaterials science and engineering C: materials for biological applicationspt_BR
dc.relation.ispartofabbreviationMater. sci. eng. C: mater. biol. appl.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2016-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume58pt_BR
dc.description.firstpage870pt_BR
dc.description.lastpage881pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0928-4931pt_BR
dc.identifier.eissn1873-0191pt_BR
dc.identifier.doi10.1016/j.msec.2015.09.071pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0928493115303908pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumber473013/2009-6pt_BR
dc.date.available2020-07-03T20:08:09Z-
dc.date.accessioned2020-07-03T20:08:09Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-07-03T20:08:09Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-07-03T20:08:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/344303-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Físico-Químicapt_BR
dc.contributor.departmentDepartamento de Engenharia de Materiais e Bioprocessospt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.subject.keywordPCLpt_BR
dc.subject.keyword17α-Methyltestosteronept_BR
dc.subject.keywordParticlespt_BR
dc.subject.keywordSupercritical fluidpt_BR
dc.identifier.source000364247500103pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-0405-3516pt_BR
dc.creator.orcid0000-0002-5813-332Xpt_BR
dc.type.formArtigopt_BR
Appears in Collections:IQ - Artigos e Outros Documentos
FEQ - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.