Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/343992
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSilva, Bruno Guzzo da-
dc.contributor.authorunicampFileti, Ana Maria Frattini-
dc.contributor.authorunicampFoglio, Mary Ann-
dc.contributor.authorunicampRuiz, Ana Lucia Tasca Gois-
dc.contributor.authorunicampRosa, Paulo de Tarso Vieira e-
dc.typeArtigopt_BR
dc.titleSupercritical carbon dioxide extraction of compounds from Schinus terebinthifolius Raddi fruits: Effects of operating conditions on global yield, volatile compounds, and antiproliferative activity against human tumor cell linespt_BR
dc.contributor.authorSilva, Bruno Guzzo da-
dc.contributor.authorFileti, Ana Maria Frattini-
dc.contributor.authorFoglio, Mary Ann-
dc.contributor.authorRuiz, Ana Lúcia Tasca Gois-
dc.contributor.authorRosa, Paulo de Tarso Vieira e-
dc.subjectDióxido de carbonopt_BR
dc.subject.otherlanguageCarbon dioxidept_BR
dc.description.abstractSchinus terebinthifolius Raddi is a South American plant with medicinal properties. We report the extraction of compounds from S. terebinthifolius fruits using supercritical CO2 (scCO2), with emphasis on the effects of scCO2 pressure (100–300 bar) and temperature (40–60 °C) on global yield, volatile compounds, and antiproliferative activity against nine human tumor cell lines. Supercritical extracts obtained at 50–60 °C, independently of pressure, showed potent activity against kidney cancer with total growth inhibition <3.9 μg/mL. Furthermore, extracts obtained at 200 bar and 50 °C showed potent activity against multidrug-resistant ovarian, prostate, and ovarian tumor cell lines, and glioma. Gas chromatography-mass spectrometry revealed the following volatile compounds: δ-3-carene, α-phellandrene, limonene, germacrene D, and caryophyllene. The results suggest that sesquiterpenes may be the metabolites responsible for the antiproliferative activity. However, future work involving fractionation of the extracts might shed light on the chemical compounds responsible for each antiproliferative activitypt_BR
dc.relation.ispartofThe journal of supercritical fluidspt_BR
dc.relation.ispartofabbreviationJ. supercrit. fluidspt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2017-
dc.language.isoengpt_BR
dc.description.volume130pt_BR
dc.description.firstpage10pt_BR
dc.description.lastpage16pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0896-8446pt_BR
dc.identifier.eissn1872-8162pt_BR
dc.identifier.doi10.1016/j.supflu.2017.07.006pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0896844617302590pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2020-06-30T19:20:34Z-
dc.date.accessioned2020-06-30T19:20:34Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-06-30T19:20:34Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-11T20:03:02Z : No. of bitstreams: 1 000412254200002.pdf: 5246176 bytes, checksum: 19a1b7754e654f360c82c7c26bb46d6a (MD5)en
dc.description.provenanceMade available in DSpace on 2020-06-30T19:20:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2017en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/343992-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Engenharia de Sistemas Químicospt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Físico-Químicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeFaculdade de Ciências Farmacêuticaspt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.subject.keywordSchinus terebinthifoliuspt_BR
dc.subject.keywordRaddipt_BR
dc.subject.keywordPink pepperpt_BR
dc.subject.keywordSupercritical fluid extractionpt_BR
dc.subject.keywordVolatile compoundspt_BR
dc.subject.keywordAntiproliferative activitypt_BR
dc.identifier.source000412254200002pt_BR
dc.creator.orcid0000-0002-0002-709Xpt_BR
dc.creator.orcid0000-0001-6826-2101pt_BR
dc.creator.orcid0000-0001-7715-4452pt_BR
dc.creator.orcid0000-0002-0844-8702pt_BR
dc.creator.orcid0000-0003-0405-3516pt_BR
dc.type.formArtigopt_BR
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