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Type: Artigo
Title: Pharmacokinetics of riluzole in beagle dogs
Author: Perdigao, Ana P. L.
Antunes, Natalicia de Jesus
Juni, Lucas T.
de Freitas, Noedi L.
Rojas-Moscoso, Julio
Correa, Silvia V. M.
da Costa, Ronaldo C.
Moreno, Ronilson A.
Mendes, Gustavo D.
de Nucci, Gilberto
Abstract: Riluzole is a benzothiazole anticonvulsant used in the treatment of patients with amyotrophic lateral sclerosis and it is being investigated for clinical use in patients with spinal cord injury. The present study evaluated the pharmacokinetics of riluzole in beagle dogs after oral dose administration. Methods The oral doses (1.5, 5, 15 and 50 mg/kg) of riluzole were administered to beagle dogs and blood samples were collected from 0 h to 24 h post drug administration. Riluzole was quantified by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Results The method was sensitive, precise, accurate and selective to riluzole quantification in plasma of beagle dogs. The pharmacokinetics following oral administration was linear from 1.5 to 15 mg/kg and the t(1/2) was 2.16, 1.5, 1.8 and 3.0 h after oral administration of 1.5, 5.0, 15 and 50 mg/kg riluzole. Conclusion The riluzole pharmacokinetics was linear up to 15 mg/kg and had a significantlyshorter t(1/2) in beagle dogs than in humans
Subject: Riluzol
Country: Alemanha
Editor: Georg Thieme Verlag
Rights: Fechado
Identifier DOI: 10.1055/a-0645-1248
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos

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