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Type: Artigo
Title: Cytogenetic abnormalities in couples with a history of primary and secondary recurrent miscarriage: a brazilian multicentric study
Author: Cavalcante, Marcelo Borges
Sarno, Manoel
Gayer, Gabriela
Meira, Joanna
Niag, Marla
Pimentel, Kleber
Luz, Ivana
Figueiredo, Bianca
Michelon, Tatiana
Neumann, Jorge
Lima, Simone
Machado, Isabela Nelly
Araujo Junior, Edward
Barini, Ricardo
Abstract: To evaluate the difference between chromosomal abnormalities between the gender of couples affected by Recurrent miscarriage (RM) and if there is an association between previous obstetric history and chromosomal abnormalities of the parents. Methods: Multicenter, retrospective, observational study from seven different RM clinics between 2006 and 2016. We enrolled 707 couples (1014 participants) with a history of RM. We compared the frequency of chromosomal abnormalities between groups of couples with primary and secondary RM and separated between women and their partners. Furthermore, we compared the prevalence of chromosomal abnormalities between groups based on the number of previous spontaneous abortions. Results: The overall prevalence of all cytogenetic abnormalities was 5.59% (n = 1414, women and their partners). Excluding cases of polymorphism and inversion of chromosome 9, which are considered variants of normality, the prevalence in all individuals was 2.26% (n = 32/1414). The comparative analysis of cases of chromosomal abnormalities among couples with primary and secondary RM based on the number of previous miscarriages (PM) revealed a similar frequency between groups. The statistical analysis of the total cases (primary PM + secondary PM) in these three groups were as follows: (a) couple, 2 pm versus 3 pm vs. >= 4 PM, p = .514; (b) women, 2 pm versus 3 pm vs. >= 4 PM, p = .347; and (3) partner, 2 pm versus 3 pm vs. >= 4 PM, p = .959. Chromosomal abnormalities were significantly more prevalent among women than among their partners (6.9 versus 4.2%; p = .027). Moreover, the distribution of leading chromosomal abnormalities among women was different compared with their partners. Among women, we observed these abnormalities in the following frequency order: mosaicism (38.8%), polymorphism (32.6%), translocation (16.3%), and inversion (12.3%). Among their partners, these abnormalities were polymorphism (73.3%), inversion (13.3%), mosaicism (6.7%), and translocation (6.7%). Conclusion: The number of PM and the history of full-term pregnancy does not correlate with an increase or decrease in the prevalence of cytogenetic abnormalities in couples with RM
Subject: Aborto habitual
Country: Reino Unido
Editor: Taylor & Francis
Rights: Fechado
Identifier DOI: 10.1080/14767058.2018.1494714
Date Issue: 2020
Appears in Collections:FCM - Artigos e Outros Documentos

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