Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/343076
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampOkubo, Márcia Yumi-
dc.contributor.authorunicampDella Torre, Adriana-
dc.contributor.authorunicampPaiva, Paula Pereira de-
dc.contributor.authorunicampRuiz, Ana Lucia Tasca Gois-
dc.contributor.authorunicampImamura, Paulo Mitsuo-
dc.contributor.authorunicampCarvalho, João Ernesto de-
dc.typeArtigopt_BR
dc.titleCoronarin D induces apoptotic cell death and cell cycle arrest in human glioblastoma cell linept_BR
dc.contributor.authorFranco, Yollanda E. M.-
dc.contributor.authorOkubo, Marcia Y.-
dc.contributor.authorTorre, Adriana D.-
dc.contributor.authorPaiva, Paula P.-
dc.contributor.authorRosa, Marcela N.-
dc.contributor.authorSilva, Viviane A. O.-
dc.contributor.authorReis, Rui M.-
dc.contributor.authorRuiz, Ana L. T. G.-
dc.contributor.authorImamura, Paulo M.-
dc.contributor.authorCarvalho, João E. de-
dc.contributor.authorLongato, Giovanna B.-
dc.subjectGlioblastomapt_BR
dc.subjectApoptosept_BR
dc.subjectProdutos biológicospt_BR
dc.subject.otherlanguageGlioblastomapt_BR
dc.subject.otherlanguageApoptosispt_BR
dc.subject.otherlanguageBiological productspt_BR
dc.description.abstractGlioblastoma (GBM) is the most frequent and highest–grade brain tumor in adults. The prognosis is still poor despite the use of combined therapy involving maximal surgical resection, radiotherapy, and chemotherapy. The development of more efficient drugs without noticeable side effects is urgent. Coronarin D is a diterpene obtained from the rhizome extract of Hedychium coronarium, classified as a labdane with several biological activities, principally anticancer potential. The aim of the present study was to determine the anti–cancer properties of Coronarin D in the glioblastoma cell line and further elucidate the underlying molecular mechanisms. Coronarin D potently suppressed cell viability in glioblastoma U–251 cell line, and also induced G1 arrest by reducing p21 protein and histone H2AX phosphorylation, leading to DNA damage and apoptosis. Further studies showed that Coronarin D increased the production of reactive oxygen species, lead to mitochondrial membrane potential depolarization, and subsequently activated caspases and ERK phosphorylation, major mechanisms involved in apoptosis. To our knowledge, this is the first analysis referring to this compound on the glioma cell line. These findings highlight the antiproliferative activity of Coronarin D against glioblastoma cell line U–251 and provide a basis for further investigation on its antineoplastic activity on brain cancerpt_BR
dc.relation.ispartofMoleculespt_BR
dc.publisher.cityBaselpt_BR
dc.publisher.countrySuíçapt_BR
dc.publisherMDPIpt_BR
dc.date.issued2019-
dc.date.monthofcirculationDec.pt_BR
dc.language.isoengpt_BR
dc.description.volume24pt_BR
dc.description.issuenumber24pt_BR
dc.description.firstpage4498pt_BR
dc.rightsAbertopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.issn1431-5165pt_BR
dc.identifier.eissn1420-3049pt_BR
dc.identifier.doi10.3390/molecules24244498pt_BR
dc.identifier.urlhttps://www.mdpi.com/1420-3049/24/24/4498pt_BR
dc.description.sponsorshipFINANCIADORA DE ESTUDOS E PROJETOS - FINEPpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberNão tempt_BR
dc.description.sponsordocumentnumber2014/06636–7; 2016/06137–6pt_BR
dc.date.available2020-06-10T13:56:31Z-
dc.date.accessioned2020-06-10T13:56:31Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-06-10T13:56:30Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-09-03T11:56:10Z : No. of bitstreams: 1 2-s2.0-85076353515.pdf: 3547396 bytes, checksum: e294bf5e768959592cd05f8c6ffbc828 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-06-10T13:56:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/343076-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Química Orgânicapt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Farmacêuticaspt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeFaculdade de Ciências Farmacêuticaspt_BR
dc.subject.keywordCoronarin Dpt_BR
dc.subject.keywordCell cycle arrestpt_BR
dc.identifier.source2-s2.0-85076353515pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-0844-8702pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-6901-6815pt_BR
dc.type.formArtigopt_BR
dc.description.sponsorNoteThis research was funded by grants from the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP 2014/06636–7 and 2016/06137–6), financiadora de Estudos e Projetos FINEP (MCTI/FINEP/MS/SCTIE/DECIT–01/2013–FPXII–BIOPLAT)pt_BR
Appears in Collections:IQ - Artigos e Outros Documentos
IB - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-85076353515.pdf3.46 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.