Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/343065
Type: Artigo
Title: Epidemiology, characterization, and diagnosis of neuropsychiatric events in systemic lupus erythematosus
Author: Amorim, Jaqueline Cristina de
Frittoli, Renan Bazuco
Pereira, Danilo
Postal, Mariana
Dertkigil, Sergio San Juan
Reis, Fabiano
Costallat, Lilian T. L.
Appenzeller, Simone
Abstract: Neuropsychiatric systemic lupus erythematosus (NPSLE) is characterized by a heterogeneity of clinical manifestations. The absence of diagnostic criteria and the lack of clinical trials is a challenge in clinical practice. Areas covered: A literature review was performed to describe epidemiology, characterization (clinical, immunological, and imaging), diagnosis and treatment of NPSLE. Classification criteria have been the first step towards a uniform definition. More recently, different attribution models have been developed to help to determine if the NP event is due to SLE. Disease activity is a major risk factor for NP events. Cytokines and autoantibodies are associated with NP events, however, only a few studies have identified risk factors for individual NP events. Expert opinion: Further research needs to search for and validate biomarkers for NPSLE and individual NP events, including neuroimaging findings, attribution models, and serologic markers. This will be a fundamental step in planning randomized control trials in the treatment of NPSLE to improve outcome
Subject: Lúpus eritematoso sistêmico
Country: Reino Unido
Editor: Taylor & Francis
Rights: Fechado
Identifier DOI: 10.1080/1744666X.2019.1564040
Address: https://www.tandfonline.com/doi/abs/10.1080/1744666X.2019.1564040
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos

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