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|Title:||Epidemiology, characterization, and diagnosis of neuropsychiatric events in systemic lupus erythematosus|
|Author:||Amorim, Jaqueline Cristina de|
Frittoli, Renan Bazuco
Dertkigil, Sergio San Juan
Costallat, Lilian T. L.
|Abstract:||Neuropsychiatric systemic lupus erythematosus (NPSLE) is characterized by a heterogeneity of clinical manifestations. The absence of diagnostic criteria and the lack of clinical trials is a challenge in clinical practice. Areas covered: A literature review was performed to describe epidemiology, characterization (clinical, immunological, and imaging), diagnosis and treatment of NPSLE. Classification criteria have been the first step towards a uniform definition. More recently, different attribution models have been developed to help to determine if the NP event is due to SLE. Disease activity is a major risk factor for NP events. Cytokines and autoantibodies are associated with NP events, however, only a few studies have identified risk factors for individual NP events. Expert opinion: Further research needs to search for and validate biomarkers for NPSLE and individual NP events, including neuroimaging findings, attribution models, and serologic markers. This will be a fundamental step in planning randomized control trials in the treatment of NPSLE to improve outcome|
|Subject:||Lúpus eritematoso sistêmico|
|Editor:||Taylor & Francis|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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