Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/342999
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFreitas, Emanuelle Dantas de-
dc.contributor.authorunicampSilva, Renata Borelli da-
dc.contributor.authorunicampSilva, Meuris Gurgel Carlos da-
dc.contributor.authorunicampVieira, Melissa Gurgel Adeodato-
dc.typeArtigopt_BR
dc.titleDevelopment and in-vitro evaluation of the extended release valsartan from sericin and alginate beadspt_BR
dc.contributor.authorFreitas, Emanuelle D.-
dc.contributor.authorSilva, Renata B. da-
dc.contributor.authorDeldotti, Sara R.-
dc.contributor.authorMarzola, Gabrielly A.-
dc.contributor.authorSilva, Meuris G. C. da-
dc.contributor.authorVieira, Melissa G. A.-
dc.subjectIn Vitropt_BR
dc.subjectAlginatospt_BR
dc.subject.otherlanguageIn Vitropt_BR
dc.subject.otherlanguageAlginatespt_BR
dc.description.abstractValsartan, a type 1 selective receptor for angiotensin, is primarily used in the treatment of hypertension and, in a minority, to treat coronary artery disease and heart failure. Among its adverse effects, it can be mentioned malaise, dizziness and headache. Furthermore, in the conventional form of release, it may cause patient non-compliance with treatment and need for multiple dosages, which lead to the possibility of reduction in therapeutic efficiency. To avoid these disadvantages, the present work aimed at the production of valsartan particles for delayed and extended release of the drug. The composition of the particles was based on the polymer blend of sericin and alginate. Sericin, present in the cocoons of the Bombyx mori silkworm, is a water soluble globular protein discharged into effluent from the silk industry. Its chemical structure allows it to be used for the formation of blends with other polymers, aiming at the improvement of its properties. Alginate, which was commercially obtained, is a polysaccharide obtained from brown algae, widely used in pharmaceutical applications. In order to evaluate the incorporation of valsartan into the aforementioned polymer blend, formulations with alginate only and formulations with different amounts of alginate initially added were developed. The evaluation was accomplished by means of incorporation efficiency and in vitro dissolution tests in simulated gastrointestinal environment. Sericin was shown to increase both the drug incorporation efficiency and the release time in enteric media. The best result was obtained for the formulation composed of the sericin and alginate blend, with the lowest amount of alginate. An 82.75 ± 2.61 % incorporation efficiency and extended release (about 28 hours) was achievedpt_BR
dc.relation.ispartofChemical engineering transactionspt_BR
dc.publisher.cityMilãopt_BR
dc.publisher.countryItáliapt_BR
dc.publisherAIDIC / Associazione Italiana Di Ingegneria Chimicapt_BR
dc.date.issued2019-
dc.date.monthofcirculationMay.pt_BR
dc.language.isoengpt_BR
dc.description.volume74pt_BR
dc.description.firstpage1537pt_BR
dc.description.lastpage1542pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.eissn2283-9216pt_BR
dc.identifier.doi10.3303/CET1974257pt_BR
dc.identifier.urlhttps://www.cetjournal.it/index.php/cet/article/view/CET1974257pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber301401/2016-0pt_BR
dc.description.sponsordocumentnumber2015/13505-9; 2016/05007-1pt_BR
dc.date.available2020-06-09T15:29:02Z-
dc.date.accessioned2020-06-09T15:29:02Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-06-09T15:29:02Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-09-03T11:56:05Z : No. of bitstreams: 1 2-s2.0-85067000254.pdf: 952122 bytes, checksum: ca9ceb459a7f93aec64b5d552c234a98 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-06-09T15:29:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/342999-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Desenvolvimento de Processos e Produtospt_BR
dc.contributor.departmentDepartamento de Desenvolvimento de Processos e Produtospt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.subject.keywordEvaluation of the Extendedpt_BR
dc.identifier.source2-s2.0-85067000254pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0003-1000-1392pt_BR
dc.creator.orcid0000-0002-3487-799Xpt_BR
dc.type.formArtigo de pesquisapt_BR
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