Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/34297
Type: Artigo de periódico
Title: Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
Author: Brenna, Sylvia Michelina Fernandes
Silva, Ismael Dale Cotrin Guerreiro da
Zeferino, Luiz Carlos
Pereira, Julia
Martinez, Edson Zachaione
Syrjänen, Kari Juhani
Abstract: The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.
Subject: p53 polymorphism
codon 72
genetic polymorphism
cervix cancer
human papillomavirus
Editor: Sociedade Brasileira de Genética
Rights: aberto
Identifier DOI: 10.1590/S1415-47572004000400005
Address: http://dx.doi.org/10.1590/S1415-47572004000400005
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000400005
Date Issue: 1-Jan-2004
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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