Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/342965
Type: Artigo
Title: Investigation of possible high-energy phosphate concentration changes in the visual cortex for different stimulus frequencies
Author: Costa, Thiago Bulhões da Silva
Landim, Ricardo Cesar Giorgetti
Barreto, Felipe Rodrigues
Silva, Elvis Lira da
Salmon, Carlos Ernesto Garrido
Castellano, Gabriela
Abstract: Many works have reported changes in the visual cortex regarding stimulation with different flickering frequencies using various neuroimaging techniques. Also, many phosphorus functional magnetic resonance spectroscopy (31P-fMRS) studies have reported high-energy phosphate (HEP) changes in the visual cortex during visual stimulation at 8 Hz, compared with rest periods. However, there have been no studies attempting to measure HEP changes during visual stimulation with different flickering frequencies. The aim of this work was to use the 31P-fMRS technique to assess possible HEP changes during visual stimulation experiments with stimuli flickering at 4 Hz or 8 Hz, and compare the results obtained with the different frequencies. Methods: Nineteen subjects participated in the study. Experiments consisted of 31P-fMRS acquisitions in a 3T magnetic resonance scanner while subjects underwent a five blocks Rest/Stimulus protocol, with stimuli flickering at either 4 Hz or 8 Hz. We assessed pH; the alpha and gamma peaks of adenosine tri-phosphate (α-ATP and γ-ATP); the ratios phosphocreatine/inorganic phosphate (Pi), and of the metabolites phosphocreatine, Pi, glycerophosphocholine, phosphoethanolamine, and glycerophosphoethanolamine with respect to α-ATP and γ-ATP; and the linewidth of the phosphocreatine peak. Results: pH was stable along acquisitions for both 4 Hz and 8 Hz. No significant changes were found for neither α-ATP, γ-ATP, metabolite ratios, nor phosphocreatine linewidth. Conclusion: This was probably due to the compromise existing between signal-to-noise ratio and temporal/spatial resolutions—the former requires long acquisitions/large voxels which possibly result in missing alterations and partial volume effects regarding changes detected by other techniques such as functional magnetic resonance imaging. These effects may have been amplified by the use of a non-localized sequence
Subject: Espectroscopia de ressonância magnética
Country: Brasil
Editor: Sociedade Brasileira de Engenharia Biomedica
Rights: Fechado
Identifier DOI: 10.1007/s42600-019-00023-0
Address: https://link.springer.com/article/10.1007%2Fs42600-019-00023-0
Date Issue: 2019
Appears in Collections:IFGW - Artigos e Outros Documentos
FEEC - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-85074836927.pdf1.45 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.