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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCosta, Amanda Ferreira-
dc.contributor.authorunicampDuran Caballero, Nelson Eduardo-
dc.typeArtigopt_BR
dc.titleNew approach for simvastatin as an antibacterial: synergistic effect with bio-synthesized silver nanoparticles against multidrug-resistant bacteriapt_BR
dc.contributor.authorFigueiredo, E. P.-
dc.contributor.authorRibeiro, J. M.-
dc.contributor.authorNishio, E. K.-
dc.contributor.authorScandorieiro, S.-
dc.contributor.authorCosta, A. F.-
dc.contributor.authorCardozo, V. F.-
dc.contributor.authorOliveira, A. G.-
dc.contributor.authorDurán, N.-
dc.contributor.authorPanagio, L. A.-
dc.contributor.authorKobayashi, R. K. T.-
dc.contributor.authorNakazato, G.-
dc.subjectNanopartículas metálicaspt_BR
dc.subject.otherlanguageMetal nanoparticlespt_BR
dc.description.abstractMultidrug-resistant bacteria such as extended-spectrum beta-lactamase (ESBL), Enterobacteriaceae, and methicillin-resistant Staphylococcus aureus (MRSA) pose a challenge to the human health care system. MRSA is among the major causes of hospital-acquired and community infections. Methods: Therefore, in the present study, we evaluated the antibacterial activity of silver nanoparticles synthesized by Fusarium oxysporum (AgNPbio) in combination with simvastatin against reference and multidrug-resistant bacterial strains. Results: Simvastatin showed a minimal inhibitory concentration (MIC) ranging from 0.062 to 0.25 mg mL−1 against MRSA. AgNPbio with a size of 77.68± 33.95 nm and zeta potential −34.6 ± 12.7 mV showed an MIC of 0.212 mg mL−1 against S. aureus including MRSA strains. The checkerboard assay and time-kill curves exhibited a synergistic effect of the simvastatin-AgNPbio combination on antibacterial activity against MRSA strains. The combination of simvastatin and AgNPbio demonstrated antibacterial activity against Escherichia coli producing ESBL. Scanning electron microscopy showed the formation of cell surface protrusions after treatment with AgNPbio and the formation of a large amorphous mass after treatment with simvastatin, both in MRSA. Conclusion: Our results indicate that the combination of AgNPbio and simvastatin could be a great future alternative in the control of bacterial infections, where, when combined with simvastatin, smaller doses of AgNPbio are required, with the same antibacterial activitypt_BR
dc.relation.ispartofInternational journal of nanomedicinept_BR
dc.publisher.cityMacclesfieldpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherDove Medical Press (Dovepress)pt_BR
dc.date.issued2019-
dc.language.isoengpt_BR
dc.description.volume14pt_BR
dc.description.firstpage7975pt_BR
dc.description.lastpage7985pt_BR
dc.rightsAbertopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.eissn1178-2013pt_BR
dc.identifier.doi10.2147/IJN.S211756pt_BR
dc.identifier.urlhttps://www.dovepress.com/new-approach-for-simvastatin-as-an-antibacterial-synergistic-effect-wi-peer-reviewed-article-IJNpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsordocumentnumber402728/2013-0pt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2020-06-08T10:39:59Z-
dc.date.accessioned2020-06-08T10:39:59Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-06-08T10:39:59Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-09-03T11:55:56Z : No. of bitstreams: 1 2-s2.0-85073575181.pdf: 3014096 bytes, checksum: f960d159977a3753806d368953eb135d (MD5)en
dc.description.provenanceMade available in DSpace on 2020-06-08T10:39:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/342867-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Química Orgânicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.subject.keywordAntibacterialpt_BR
dc.subject.keywordMultidrug-resistant bacterialpt_BR
dc.subject.keywordStatinspt_BR
dc.subject.keywordSynergismpt_BR
dc.identifier.source2-s2.0-85073575181pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-8372-5143pt_BR
dc.type.formArtigo originalpt_BR
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