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dc.contributor.authorunicampSouza, Renato Teixeira-
dc.contributor.authorunicampMayrink, Jussara-
dc.contributor.authorunicampLeite, Debora Farias Batista-
dc.contributor.authorunicampPassini Júnior, Renato-
dc.contributor.authorunicampCecatti, José Guilherme-
dc.titleClinical and epidemiological factors associated with spontaneous preterm birth: a multicentre cohort of low risk nulliparous womenpt_BR
dc.contributor.authorSouza, R.T.-
dc.contributor.authorCosta, M.L.-
dc.contributor.authorMayrink, J.-
dc.contributor.authorFeitosa, F.E.-
dc.contributor.authorFilho, E.A.R.-
dc.contributor.authorLeite, D.F.-
dc.contributor.authorVettorazzi, J.-
dc.contributor.authorCalderon, I.M.-
dc.contributor.authorSousa, M.H.-
dc.contributor.authorPassini Junior, R.-
dc.contributor.authorBaker, P.N.-
dc.contributor.authorKenny, L.-
dc.contributor.authorCecatti, J.G.-
dc.contributor.authorParpinelli, M.A.-
dc.contributor.authorFernandes, K.G.-
dc.contributor.authorGuida, J.P.-
dc.contributor.authorSantana, D.S.-
dc.contributor.authorFranchini, K.G.-
dc.contributor.authorCassettari, B.F.-
dc.contributor.authorPfitscher, L.-
dc.contributor.authorBrust, L.-
dc.contributor.authorMelo Junior, E.F.-
dc.contributor.authorAnacleto, D.-
dc.contributor.authorde Lucena, D.-
dc.contributor.authorSousa, B.-
dc.subjectTrabalho de parto prematuropt_BR
dc.subject.otherlanguageObstetric labor, Prematurept_BR
dc.description.abstractThe objective of this study was to determine incidence and risk factors associated with spontaneous preterm birth (sPTB). It was a prospective multicentre cohort study performed in five Brazilian referral maternity hospitals and enrolling nulliparous women at 19–21 weeks. Comprehensive maternal data collected during three study visits were addressed as potentially associated factors for sPTB. Bivariate and multivariate analysis estimated risk ratios. The main outcomes measures were birth before 37 weeks due to spontaneous preterm labour or premature rupture of membranes (sPTB). The comparison group was comprised of women with term births (≥37weeks). Outcome data was available for 1,165 women, 6.7% of whom had sPTB, 16% had consumed alcohol and 5% had used other illicit drugs during the first half of pregnancy. Current drinking at 19–21 weeks (RR 3.96 95% CI [1.04–15.05]) and a short cervix from 18–24 weeks (RR 4.52 95% CI [1.08–19.01]) correlated with sPTB on bivariate analysis. Increased incidence of sPTB occurred in underweight women gaining weight below quartile 1 (14.8%), obese women gaining weight above quartile 3 (14.3%), women with a short cervix (<25 mm) at 18–24 weeks (31.2%) and those with a short cervix and vaginal bleeding in the first half of pregnancy (40%). Cervical length (RRadj 4.52 95% CI [1.08–19.01]) was independently associated with sPTB. In conclusion, the incidence of sPTB increased in some maternal phenotypes, representing potential groups of interest, the focus of preventive strategies. Similarly, nulliparous women with a short cervix in the second trimester require further explorationpt_BR
dc.relation.ispartofScientific reportspt_BR
dc.relation.ispartofabbreviationSci reppt_BR
dc.publisher.countryReino Unidopt_BR
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dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Tocoginecologiapt_BR
dc.contributor.departmentDepartamento de Tocoginecologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.description.sponsorNoteBill and Melinda Gates Foundation: OPP1107597pt_BR
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