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Type: Artigo
Title: Impact of SNPs/haplotypes of IL10 and IFNG on the development of diffuse large B-Cell lymphoma
Author: Marangon, Amanda Vansan
Colli, Cristiane Maria
Cardozo, Daniela Maira
Laguila Visentainer, Jeane Eliete
Sell, Ana Maria
Guimaraes, Fernando
Dutra Marques, Silvia Barbosa
Lieber, Sophia Rocha
Penteado Aranha, Francisco Jose
Zulli, Roberto
de Souza, Victor Hugo
de Souza, Carmino Antonio
Abstract: The purpose of this study was to assess the influence of single-nucleotide polymorphisms (SNPs) on cytokine genes in the development of diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients and 221 controls were investigated. Among them, 97 patients treated with R-CHOP were subdivided into two groups: (i) complete remission of the disease and (ii) patients who progressed to death, relapsed, or had disease progression. The SNPs investigated by PCR-SSP were TNF -308G>A (rs1800629), IFNG +874A>T (rs2430561), IL6 -174G>C (rs1800795), IL10 -1082A>G (rs1800896), IL10 -819C>T (rs1800871), IL10 -592C>A (rs1800872), and TGFB1 codon10T>C (rs1982073) and codon25G>C (rs1800471). In general, the genotypes that have been associated in the literature with lower production or intermediate production of IL-10 and higher production of IFN-gamma were associated with the protection of the development of the disease, possibly favoring the Th1 immune response and diminishing the capacity of cell proliferation. However, patients receiving R-CHOP treatment presented unfavorable prognoses in the presence of genotypes related to the intermediate production of IL-10 and high production of TGF-beta 1, indicating that cytokines may be related to the response to treatment and action mechanisms of Rituximab
Subject: Haplótipos
Linfoma difuso de grandes células B
Country: Reino Unido
Editor: Hindawi
Rights: Aberto
Identifier DOI: 10.1155/2019/2137538
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos
HEMO - Artigos e Outros Documentos

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