Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/342583
Type: Artigo
Title: Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate
Author: Teixeira, Giovana Rampazzo
Mendes, Leonardo Oliveira
Veras, Allice Santos Cruz
Thorpe, Hayley Hope Allyssa
Fávaro, Wagner José
Chuffa, Luiz Gustavo de Almeida
Pinheiro, Patrícia Fernanda Felipe
Martinez, Francisco Eduardo
Abstract: Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of the lipid metabolism process. We investigated the effect of physical resistance training on lipid metabolism and apoptosis in the adult Wistar rat prostate. Two experimental groups represented sedentary and physical resistance training. Three days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a physical resistance exercise protocol. Two days after the last training session, rats were anesthetized and sacrificed for blood and prostate analysis. Physical exercise improved feeding efficiency, decreased weight gain, regulated the serum-lipid profile, and modulated insulin-like growth factor-1 (IGF-1) and free testosterone concentration. Furthermore, upregulation of cluster of differentiation 36 (CD36), sterol regulatory element binding protein-1 (SREBP-1), sterol regulatory element-binding protein cleavage-activating protein (SCAP), and reduced lysosome membrane protein (LIMPII) expression were also observed in the blood and prostates of trained rats. Consistent with these results, caspase-3 expression was upregulating and the BCL-2/Bax index ratio was decreased in trained rats relative to sedentary animals. Physical exercise improved feeding efficiency, decreased weight gain, regulated the serum-lipid profile, and modulated insulin-like growth factor-1 (IGF-1) and free testosterone concentration. Furthermore, upregulation of cluster of differentiation 36 (CD36), sterol regulatory element binding protein-1 (SREBP-1), sterol regulatory element-binding protein cleavage-activating protein (SCAP), and reduced lysosome membrane protein (LIMPII) expression were also observed in the blood and prostates of trained rats. Consistent with these results, caspase-3 expression was upregulating and the BCL-2/Bax index ratio was decreased in trained rats relative to sedentary animals
Subject: Exercícios físicos
Apoptose
Antígenos CD36
Country: Reino Unido
Editor: BioMed Central
Rights: Aberto
Identifier DOI: 10.1186/s12944-020-1195-0
Address: https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-1195-0
Date Issue: 2020
Appears in Collections:IB - Artigos e Outros Documentos

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