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Type: Artigo
Title: Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies
Author: Tholance, Yannick
Moritz, Christian Peter
Rosier, Carole
Ferraud, Karine
Lassabliere, Francois
Reynaud-Federspiel, Evelyne
Franca Jr., Marcondes C.
Martinez, Alberto R. M.
Camdessanche, Jean-Philippe
Antoine, Jean-Christophe
Adams, David
Cauquil, Cecile
Attarian, Shahram
Delmont, Emilien
Blanchet-Fourcade, Genevieve
Callias, Celine
Cassereau, Julien
Choumert, Ariane
Clavelou, Pierre
Creange, Alain
Di Virgilio, Gabriella
Echaniz-Laguna, Andoni
Faucher, Benoit
Galea, Ian
Genestet, Steeve
Gueguen, Antoine
Ion, Ioana M.
Juntas-Morales, Raul
Taieb, Guillaume
Kuntzer, Thierry
Lagrange, Emmeline
Leger, Jean-Marc
Stojkovic, Tanya
Lepetit, Maud
Magy, Laurent
Mas, Julie
Michaud, Maud
Mouthon-Reignier, Capucine
Neau, Jean-Philippe
Ozsancak, Canan
Pereon, Yann
Perrotte, Paul
Puma, Angela
Rajabally, Yusuf A.
Rinaldi, Simon
Rouaud, Violaine
Sole, Guilhem
Tard, Celine
Vallet, Anne-Evelyne
Vial, Christophe
Abstract: Sensory neuropathies (SNs) are often classified as idiopathic even if immunological mechanisms can be suspected. Antibodies against the intracellular domain of the fibroblast growth factor receptor 3 (FGFR3) possibly identify a subgroup of SN affecting mostly the dorsal root ganglion (DRG). The aim of this study was to identify the frequency of anti-FGFR3 antibodies and the associated clinical pattern in a large cohort of patients with SN. A prospective, multicentric, European and Brazilian study included adults with pure SN. Serum anti-FGRF3 antibodies were analysed by ELISA. Detailed clinical and paraclinical data were collected for each anti-FGFR3-positive patient and as control for anti-FGFR3-negative patients from the same centres ('center-matched'). Sixty-five patients out of 426 (15%) had anti-FGFR3 antibodies, which were the only identified autoimmune markers in 43 patients (66%). The neuropathy was non-length dependent in 89% and classified as sensory neuronopathy in 64%, non-length-dependent small fibre neuropathy in 17% and other neuropathy in 19%. Specific clinical features occurred after 5-6 years of evolution including frequent paresthesia, predominant clinical and electrophysiological involvement of the lower limbs, and a less frequent mixed large and small fibre involvement. Brazilians had a higher frequency of anti-FGFR3 antibodies than Europeans (36% vs 13%, p<0.001), and a more frequent asymmetrical distribution of symptoms (OR 169, 95% CI 3.4 to 8424). Anti-FGFR3 antibodies occur in a subgroup of SN probably predominantly affecting the DRG. Differences between Europeans and Brazilians could suggest involvement of genetic or environmental factors
Subject: Doenças autoimunes
Country: Reino Unido
Editor: BMJ
Rights: Fechado
Identifier DOI: 10.1136/jnnp-2019-321849
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos

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