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http://repositorio.unicamp.br/jspui/handle/REPOSIP/342582
Type: | Artigo |
Title: | Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies |
Author: | Tholance, Yannick Moritz, Christian Peter Rosier, Carole Ferraud, Karine Lassabliere, Francois Reynaud-Federspiel, Evelyne Franca Jr., Marcondes C. Martinez, Alberto R. M. Camdessanche, Jean-Philippe Antoine, Jean-Christophe Adams, David Cauquil, Cecile Attarian, Shahram Delmont, Emilien Blanchet-Fourcade, Genevieve Callias, Celine Cassereau, Julien Choumert, Ariane Clavelou, Pierre Creange, Alain Di Virgilio, Gabriella Echaniz-Laguna, Andoni Faucher, Benoit Galea, Ian Genestet, Steeve Gueguen, Antoine Ion, Ioana M. Juntas-Morales, Raul Taieb, Guillaume Kuntzer, Thierry Lagrange, Emmeline Leger, Jean-Marc Stojkovic, Tanya Lepetit, Maud Magy, Laurent Mas, Julie Michaud, Maud Mouthon-Reignier, Capucine Neau, Jean-Philippe Ozsancak, Canan Pereon, Yann Perrotte, Paul Puma, Angela Rajabally, Yusuf A. Rinaldi, Simon Rouaud, Violaine Sole, Guilhem Tard, Celine Vallet, Anne-Evelyne Vial, Christophe |
Abstract: | Sensory neuropathies (SNs) are often classified as idiopathic even if immunological mechanisms can be suspected. Antibodies against the intracellular domain of the fibroblast growth factor receptor 3 (FGFR3) possibly identify a subgroup of SN affecting mostly the dorsal root ganglion (DRG). The aim of this study was to identify the frequency of anti-FGFR3 antibodies and the associated clinical pattern in a large cohort of patients with SN. A prospective, multicentric, European and Brazilian study included adults with pure SN. Serum anti-FGRF3 antibodies were analysed by ELISA. Detailed clinical and paraclinical data were collected for each anti-FGFR3-positive patient and as control for anti-FGFR3-negative patients from the same centres ('center-matched'). Sixty-five patients out of 426 (15%) had anti-FGFR3 antibodies, which were the only identified autoimmune markers in 43 patients (66%). The neuropathy was non-length dependent in 89% and classified as sensory neuronopathy in 64%, non-length-dependent small fibre neuropathy in 17% and other neuropathy in 19%. Specific clinical features occurred after 5-6 years of evolution including frequent paresthesia, predominant clinical and electrophysiological involvement of the lower limbs, and a less frequent mixed large and small fibre involvement. Brazilians had a higher frequency of anti-FGFR3 antibodies than Europeans (36% vs 13%, p<0.001), and a more frequent asymmetrical distribution of symptoms (OR 169, 95% CI 3.4 to 8424). Anti-FGFR3 antibodies occur in a subgroup of SN probably predominantly affecting the DRG. Differences between Europeans and Brazilians could suggest involvement of genetic or environmental factors |
Subject: | Doenças autoimunes |
Country: | Reino Unido |
Editor: | BMJ |
Rights: | Fechado |
Identifier DOI: | 10.1136/jnnp-2019-321849 |
Address: | https://jnnp.bmj.com/content/91/1/49 |
Date Issue: | 2019 |
Appears in Collections: | FCM - Artigos e Outros Documentos |
Files in This Item:
File | Description | Size | Format | |
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000507335200012.pdf | 1.47 MB | Adobe PDF | View/Open |
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