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Type: Artigo
Title: Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes
Author: Admoni, Sharon Nina
Santos-Bezerra, Daniele Pereira
Perez, Ricardo Vesoni
Patente, Thiago Andrade
Monteiro, Maria Beatriz
Cavaleiro, Ana Mercedes
Parisi, Maria Candida
Neto, Arnaldo Moura
Pavin, Elizabeth Joao
Queiroz, Marcia Silva
Nery, Marcia
Correa-Giannella, Maria Lucia
Abstract: Cardiac autonomic neuropathy is a neglected diabetic chronic complication for which genetic predictors are rarely reported. Oxidative stress is implicated in the pathogenesis of microvascular complications, and glutathione peroxidase 4 is involved in the detoxification of peroxides and of reactive oxygen species. Thus, the association of a functional variant in the gene encoding glutathione peroxidase 4 (rs713041) with this diabetic complication was investigated in 341 individuals with type 1 diabetes evaluated for cardiac autonomic neuropathy status (61.7% women, 34 [27–42] years old; diabetes duration: 21 [15–27] years; HbA1c: 8.3% [7.4–9.4]; as median [interquartile interval]). Cardiac autonomic neuropathy was present in 29% of the participants. There was an inverse association of the minor T allele of rs713041 with cardiac autonomic neuropathy (odds ratio=0.39; 95% confidence interval=0.17–0.90; p=0.0271) after adjustment for potential confounders. The functional glutathione peroxidase 4 variant rs713041 modulated the risk for cardiac autonomic neuropathy in the studied population with type 1 diabetes
Subject: Doenças do sistema nervoso
Estresse oxidativo
Diabetes Mellitus tipo 1
Country: Reino Unido
Editor: Sage
Rights: Fechado
Identifier DOI: 10.1177/1479164118820641
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos

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