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Type: Artigo
Title: High levels of polypharmacy in rheumatoid arthritis—a challenge not covered by current management recommendations : data from a large real-life study
Author: Gomides, Ana Paula M.
Gomides A.P.M.
Albuquerque C.P.
Santos A.B.V.
Amorim R.B.C.
Bértolo M.B.
Júnior P.L.
Santos I.A.
Giorgi R.D.
Sacilotto N.C.
Radominski S.C.
Borghi F.M.
Guimarães M.F.B.R.
Pinto M.R.C.
Resende G.G.
Bonfiglioli K.R.
Carriço H.
Sauma M.F.L.C.
Sauma M.L.
Medeiros J.B.
Pereira I.A.
Castro G.R.W.
Brenol C.V.
Xavier R.M.
Mota L.M.H.
Pinheiro G.R.C.
Abstract: Rheumatoid arthritis (RA) is associated with high frequency of comorbidities and increased risk of polypharmacy. Although there is a great potential for complications, there is a gap in literature on polypharmacy in patients with rheumatic arthritis. To evaluate the prevalence and factors associated with polypharmacy in a population in a real-life setting. Methods: A cross-sectional multicenter study was conducted in Brazil. Patients underwent clinical evaluation and medical records analysis. Polypharmacy was considered as a dependent variable. To test independent variables, we used Poisson regression. We evaluated 792 patients (89% female, median age 56.6 years). Median duration of disease was 12.7 years, 78.73% had a positive rheumatoid factor. The median of disease activity score-28 was 3.5 (disease with mild activity), median of the clinical disease activity index score was 9, and median of health assessment questionnaire-disability index was 0.875; 47% used corticosteroids, 9.1% used nonsteroidal anti-inflammatory drugs, 90.9% used synthetic disease-modifying antirheumatic drugs, 35.7% used biologic disease-modifying antirheumatic drugs (DMARDs). In total, 537 (67.9%) patients used 5 or more drugs. Polypharmacy showed a relationship with a number of comorbidities and use of specific drugs (corticosteroids, methotrexate, and biological DMARDs). We found a high prevalence of polypharmacy (67.9%) in RA. Solutions to management this problem should be stimulated
Subject: Artrite reumatóide
Country: Estados Unidos
Editor: Sage
Rights: Fechado
Identifier DOI: 10.1177/0897190019869158
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos

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