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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampVanzela, Emerielle Cristine-
dc.contributor.authorunicampBoschero, Antonio Carlos-
dc.contributor.authorunicampCarneiro, Everardo Magalhães-
dc.typeArtigopt_BR
dc.titleProtein restriction in early life increases intracellular calcium and insulin secretion, but does not alter expression of SNARE proteins during pregnancypt_BR
dc.contributor.authorMarin, Bianca Karine-
dc.contributor.authorde Lima Reis, Silvia Regina-
dc.contributor.authorSilva Ramalho, Albina de Fatima-
dc.contributor.authorLemes, Simone Ferreira-
dc.contributor.authorMarin, Leonardo-
dc.contributor.authorVanzela, Emerielle Cristine-
dc.contributor.authorBoschero, Antonio Carlos-
dc.contributor.authorCarneiro, Everardo Magalhaes-
dc.contributor.authorLatorraca, Marcia Queiroz-
dc.contributor.authorArantes, Vanessa Cristina-
dc.contributor.authorde Barros Reis, Marise Auxiliadora-
dc.subjectInsulinapt_BR
dc.subject.otherlanguageInsulinpt_BR
dc.description.abstractWe investigated the kinetics of glucose-induced insulin secretion and their relationship with [Ca2+](i) and the expression of protein from exocytotic machinery in islets from recovered pregnant and long-term protein-deficient pregnant rats. Isolated islets were evaluated from control-fed pregnant (CP), protein-deficient pregnant (DP), control-fed non-pregnant (CNP) and protein-deficient non-pregnant (DNP) female adult rats, and from protein-deficient pregnant (RP) and non-pregnant (RNP) rats that were recovered after weaning. The insulin responses to glucose during the first phase of secretion were higher in RP than in CP groups, and both were higher than in the DP group. Islets from RP rats displayed a rapid increase in insulin release (first phase), followed by a plateau that was maintained thereafter. The [Ca2+](i) in islets from the protein-deficient groups was lower than in the control groups, and both were lower than in the RP and RNP groups. SNAP-25 was increased in islets from pregnant rats independently of their nutritional status, and the syntaxin-1A content was reduced in islets from the RP rats compared with the RNP rats. The VAMP2 content was similar among the groups. Thus, protein restriction during intrauterine life and lactation increased insulin secretion during pregnancy, attributable, in part, to increased [Ca2+](i), and independent of an alteration of expression of SNARE proteinspt_BR
dc.relation.ispartofExperimental physiologypt_BR
dc.relation.ispartofabbreviationExp. physiol.pt_BR
dc.publisher.cityChichesterpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2019-
dc.date.monthofcirculationJulypt_BR
dc.language.isoengpt_BR
dc.description.volume104pt_BR
dc.description.issuenumber7pt_BR
dc.description.firstpage1029pt_BR
dc.description.lastpage1037pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0958-0670pt_BR
dc.identifier.eissn1469-445Xpt_BR
dc.identifier.doi10.1113/EP087045pt_BR
dc.identifier.urlhttps://physoc.onlinelibrary.wiley.com/doi/full/10.1113/EP087045pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsordocumentnumber620106/2008-5; 479362/2011-4pt_BR
dc.description.sponsordocumentnumber022/2007pt_BR
dc.date.available2020-06-02T16:04:39Z-
dc.date.accessioned2020-06-02T16:04:39Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-06-02T16:04:39Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-09-03T11:55:26Z : No. of bitstreams: 1 000483742500010.pdf: 935902 bytes, checksum: a6c0036250055c52307c9ce11437f859 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-06-02T16:04:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/342450-
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordInsulin secretionpt_BR
dc.subject.keywordIntracellular Ca2+pt_BR
dc.subject.keywordNutritional recoverypt_BR
dc.subject.keywordPregnancypt_BR
dc.subject.keywordProtein-deficient dietpt_BR
dc.subject.keywordSNARE proteinspt_BR
dc.identifier.source000483742500010pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-3212-369Xpt_BR
dc.type.formArtigo de pesquisapt_BR
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