Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/342321
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampLopes, Raquel Müller Gonçalves-
dc.typeArtigopt_BR
dc.titleKynurenine elevation correlates with T regulatory cells increase in acute plasmodium vivax infection : a pilot studypt_BR
dc.contributor.authordos Santos, Rafaella Oliveira-
dc.contributor.authorGoncalves-Lopes, Raquel M.-
dc.contributor.authorLima, Nathalia F.-
dc.contributor.authorScopel, Kezia K. G.-
dc.contributor.authorFerreira, Marcelo U.-
dc.contributor.authorLalwani, Pritesh-
dc.subjectInflamaçãopt_BR
dc.subject.otherlanguageInflammationpt_BR
dc.description.abstractDisease-tolerance mechanisms limit infection severity by preventing tissue damage; however, the underlying mechanisms in human malaria are still unclear. Tryptophan (TRP), an essential amino acid, is catabolized into tolerogenic metabolites, kynurenines (KYN), by indoleamine 2,3-dioxygenase 1 (IDO1), which can induce Foxp3+ T regulatory cells (Tregs). In this study, we evaluated the relationship of these metabolites with Treg-mediated tolerance induction in acute malaria infections. We performed a cross-sectional study that evaluated asymptomatic, symptomatic malaria patients and endemic control patient groups. We assessed plasmatic concentration of cytokines by ELISA. Plasmatic TRP and KYN levels were measured by HPLC. Peripheral T regulatory cells were measured and phenotyped by flow cytometry. The KYN/TRP ratio was significantly elevated in asymptomatic and symptomatic Plasmodium infection, compared to healthy controls. Also, Th1 and Th2 cytokines were elevated in the acute phase of malaria disease. IFN-gamma increase in acute phase was positively correlated with the KYN/TRP ratio and KYN elevation was positively correlated with the increase of peripheral FoxP3+ T regulatory cells. Additional studies are needed not only to identify innate mechanisms that increase tryptophan catabolism but also the role of Tregs in controlling malaria-induced pathology and malaria tolerance by the hostpt_BR
dc.relation.ispartofParasite immunologypt_BR
dc.relation.ispartofabbreviationParasite immunol.pt_BR
dc.publisher.cityChichesterpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2020-
dc.date.monthofcirculationMar.pt_BR
dc.language.isoengpt_BR
dc.description.volume42pt_BR
dc.description.issuenumber3pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0141-9838pt_BR
dc.identifier.eissn1365-3024pt_BR
dc.identifier.doi10.1111/pim.12689pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/pim.12689pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO AMAZONAS - FAPEAMpt_BR
dc.description.sponsordocumentnumber470315/2012-1; 462245/2014-4; 436097/2018-4pt_BR
dc.description.sponsordocumentnumber2010/52146-0pt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.date.available2020-06-01T13:48:04Z-
dc.date.accessioned2020-06-01T13:48:04Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-06-01T13:48:04Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-09-03T11:56:29Z : No. of bitstreams: 1 000506937500001.pdf: 960576 bytes, checksum: ae64169f256aaaf768c585ba196f8971 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-06-01T13:48:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/342321-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.subject.keywordKynureninept_BR
dc.subject.keywordPlasmodiumpt_BR
dc.subject.keywordT regulatory cells and immunosuppressionpt_BR
dc.subject.keywordTryptophanpt_BR
dc.identifier.source000506937500001pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formRelatório brevept_BR
dc.identifier.articleide12689pt_BR
Appears in Collections:HEMO - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000506937500001.pdf938.06 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.