Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/342319
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMizobuti, Daniela Sayuri-
dc.contributor.authorunicampHermes, Túlio de Almeida-
dc.contributor.authorunicampKido, Larissa Akemi-
dc.contributor.authorunicampCagnon, Valéria Helena Alves-
dc.contributor.authorunicampMinatel, Elaine-
dc.typeArtigopt_BR
dc.titlePhotobiomodulation therapy for attenuating the dystrophic phenotype of Mdx micept_BR
dc.contributor.authorMacedo, Aline Barbosa-
dc.contributor.authorMizobuti, Daniela Sayuri-
dc.contributor.authorHermes, Tulio de Almeida-
dc.contributor.authorMancio, Rafael Dias-
dc.contributor.authorPertille, Adriana-
dc.contributor.authorKido, Larissa Akemi-
dc.contributor.authorAlves Cagnon, Valeria Helena-
dc.contributor.authorMinatel, Elaine-
dc.subjectFenótipopt_BR
dc.subject.otherlanguagePhenotypept_BR
dc.description.abstractThis study analyzed photobiomodulation therapy (PBMT) effects on regenerative, antioxidative, anti-inflammatory and angiogenic markers in the dystrophic skeletal muscle of mdx mice, the experimental model of Duchenne muscular dystrophy (DMD), during the acute phase of dystrophy disease. The following groups were set up: Ctrl (control group of normal wild-type mice; C57BL/10); mdx (untreated mdx mice); mdxPred (mdx mice treated with prednisolone) and mdxLA (mdx mice treated with PBMT). The PBMT was carried out using an Aluminum Gallium Arsenide (AIGaAs; IBRAMED (R) laserpulse) diode, 830 nm wavelength, applied on the dystrophic quadriceps muscle. The mdxLA group showed a degenerative and regenerative area reduction simultaneously with a MyoD level increase, ROS production and inflammatory marker reduction and up-regulation in the VEGF factor. In addition, PBMT presented similar effects to prednisolone treatment in most of the parameters analyzed. In conclusion, our results indicate that PBMT in the parameters selected attenuated the dystrophic phenotype of mdx mice, improving skeletal muscle regeneration; reducing the oxidative stress and inflammatory process; and up-regulating the angiogenic markerpt_BR
dc.relation.ispartofPhotochemistry and photobiologypt_BR
dc.relation.ispartofabbreviationPhotochem. photobiol.pt_BR
dc.publisher.cityHoboken, NJpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherWileypt_BR
dc.date.issued2020-
dc.date.monthofcirculationJan./Feb.pt_BR
dc.language.isoengpt_BR
dc.description.volume96pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage200pt_BR
dc.description.lastpage207pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0031-8655pt_BR
dc.identifier.eissn1751-1097pt_BR
dc.identifier.doi10.1111/php.13179pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/php.13179pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumber17732-4; 13pt_BR
dc.date.available2020-06-01T12:48:15Z-
dc.date.accessioned2020-06-01T12:48:15Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-06-01T12:48:14Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:17:39Z : No. of bitstreams: 1 000507533000023.pdf: 1588231 bytes, checksum: 9d7ae505808b3fbe93c3d175be778d14 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-06-01T12:48:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/342319-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.identifier.source000507533000023pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-2937-3890pt_BR
dc.creator.orcid0000-0002-3653-8035pt_BR
dc.creator.orcid0000-0001-5331-7376pt_BR
dc.creator.orcid0000-0001-9863-0761pt_BR
dc.type.formArtigo de pesquisapt_BR
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