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Type: Artigo
Title: Photobiomodulation therapy for attenuating the dystrophic phenotype of Mdx mice
Author: Macedo, Aline Barbosa
Mizobuti, Daniela Sayuri
Hermes, Tulio de Almeida
Mancio, Rafael Dias
Pertille, Adriana
Kido, Larissa Akemi
Alves Cagnon, Valeria Helena
Minatel, Elaine
Abstract: This study analyzed photobiomodulation therapy (PBMT) effects on regenerative, antioxidative, anti-inflammatory and angiogenic markers in the dystrophic skeletal muscle of mdx mice, the experimental model of Duchenne muscular dystrophy (DMD), during the acute phase of dystrophy disease. The following groups were set up: Ctrl (control group of normal wild-type mice; C57BL/10); mdx (untreated mdx mice); mdxPred (mdx mice treated with prednisolone) and mdxLA (mdx mice treated with PBMT). The PBMT was carried out using an Aluminum Gallium Arsenide (AIGaAs; IBRAMED (R) laserpulse) diode, 830 nm wavelength, applied on the dystrophic quadriceps muscle. The mdxLA group showed a degenerative and regenerative area reduction simultaneously with a MyoD level increase, ROS production and inflammatory marker reduction and up-regulation in the VEGF factor. In addition, PBMT presented similar effects to prednisolone treatment in most of the parameters analyzed. In conclusion, our results indicate that PBMT in the parameters selected attenuated the dystrophic phenotype of mdx mice, improving skeletal muscle regeneration; reducing the oxidative stress and inflammatory process; and up-regulating the angiogenic marker
Subject: Fenótipo
Country: Estados Unidos
Editor: Wiley
Rights: Fechado
Identifier DOI: 10.1111/php.13179
Date Issue: 2020
Appears in Collections:IB - Artigos e Outros Documentos

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