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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGrazzia, Nathalia-
dc.contributor.authorunicampGomes, Natália Eloize da Silva-
dc.contributor.authorunicampGadelha, Fernanda Ramos-
dc.contributor.authorunicampMiguel, Danilo Ciccone-
dc.contributor.authorunicampCauz, Ana Carolina Guimarães-
dc.contributor.authorunicampBrocchi, Marcelo-
dc.typeArtigopt_BR
dc.titleWater-soluble glutamic acid derivatives produced in culture by Penicillium solitum IS1-A from King George Island, Maritime Antarcticapt_BR
dc.contributor.authorRodríguez, J.P.G.-
dc.contributor.authorBernardi, D.I.-
dc.contributor.authorGubiani, J.R.-
dc.contributor.authorDe Oliveira, J.M.-
dc.contributor.authorMorais-Urano, R.P.-
dc.contributor.authorBertonha, A.F.-
dc.contributor.authorBandeira, K.F.-
dc.contributor.authorBulla, J.I.Q.-
dc.contributor.authorSette, L.D.-
dc.contributor.authorFerreira, A.G.-
dc.contributor.authorBatista, J.M.-
dc.contributor.authorSilva, T.D.S.-
dc.contributor.authorSantos, R.A.D.-
dc.contributor.authorMartins, C.H.G.-
dc.contributor.authorLira, S.P.-
dc.contributor.authorCunha, M.G.D.-
dc.contributor.authorTrivella, D.B.B.-
dc.contributor.authorGrazzia, N.-
dc.contributor.authorGomes, N.E.S.-
dc.contributor.authorGadelha, F.-
dc.contributor.authorMiguel, D.C.-
dc.contributor.authorCauz, A.C.G.-
dc.contributor.authorBrocchi, M.-
dc.contributor.authorBerlinck, R.G.S.-
dc.subjectDicroísmo circularpt_BR
dc.subject.otherlanguageCircular dichroismpt_BR
dc.description.abstractA new method of screening was developed to generate 770 organic and water-soluble fractions from extracts of nine species of marine sponges, from the growth media of 18 species of marine-derived fungi, and from the growth media of 13 species of endophytic fungi. The screening results indicated that water-soluble fractions displayed significant bioactivity in cytotoxic, antibiotic, anti-Leishmania, anti-Trypanosoma cruzi, and inhibition of proteasome assays. Purification of water-soluble fractions from the growth medium of Penicillium solitum IS1-A provided the new glutamic acid derivatives solitumine A (1), solitumine B (2), and solitumidines A-D (3-6). The structures of compounds 1-6 have been established by analysis of spectroscopic data, chemical derivatizations, and vibrational circular dichroism calculations. Although no biological activity could be observed for compounds 1-6, the new structures reported for 1-6 indicate that the investigation of water-soluble natural products represents a relevant strategy in finding new secondary metabolitespt_BR
dc.relation.ispartofJournal of natural productspt_BR
dc.relation.ispartofabbreviationJ. nat. prod.pt_BR
dc.publisher.cityWashington, DCpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherAmerican Chemical Societypt_BR
dc.date.issued2020-
dc.language.isoengpt_BR
dc.description.volume83pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage55pt_BR
dc.description.lastpage65pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.issn0163-3864pt_BR
dc.identifier.eissn1520-6025pt_BR
dc.identifier.doi10.1021/acs.jnatprod.9b00635pt_BR
dc.identifier.urlhttps://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.9b00635pt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber2013/50228-8; 2014/ 25222-9; 2016/21341-9; 2017/06014-4; 2013/23153-7; 2016/16033-3pt_BR
dc.date.available2020-05-29T20:28:08Z-
dc.date.accessioned2020-05-29T20:28:08Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-05-29T20:28:08Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:15:51Z : No. of bitstreams: 1 2-s2.0-85078375879.pdf: 2818537 bytes, checksum: 081c9f452d34bfab15ede52d10adb988 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-29T20:28:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/342300-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.departmentDepartamento Biologia Animalpt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Genética, Evolução, Microbiologia e Imunologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordMetabolismpt_BR
dc.subject.keywordOrganic polymerspt_BR
dc.subject.keywordAbsolute configurationpt_BR
dc.subject.keywordPharmaceuticalspt_BR
dc.identifier.source2-s2.0-85078375879pt_BR
dc.creator.orcid0000-0002-8058-7731pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-1075-8830pt_BR
dc.creator.orcid0000-0003-0522-6562pt_BR
dc.creator.orcid0000-0002-5964-1510pt_BR
dc.creator.orcid0000-0002-3020-531Xpt_BR
dc.type.formArtigopt_BR
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